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Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome

Epilepsy and psychiatric comorbidities are frequently associated, but their common biological substrate is unknown. We have previously reported altered structural elements and neurotrophins (NTs) expression in mesial temporal lobe epilepsy (MTLE) patients with psychiatric comorbidities. NTs receptor...

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Autores principales: Kandratavicius, Ludmyla, Hallak, Jaime Eduardo, Carlotti, Carlos Gilberto, Assirati, Joao Alberto, Leite, Joao Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149196/
https://www.ncbi.nlm.nih.gov/pubmed/25027171
http://dx.doi.org/10.1186/s40478-014-0081-2
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author Kandratavicius, Ludmyla
Hallak, Jaime Eduardo
Carlotti, Carlos Gilberto
Assirati, Joao Alberto
Leite, Joao Pereira
author_facet Kandratavicius, Ludmyla
Hallak, Jaime Eduardo
Carlotti, Carlos Gilberto
Assirati, Joao Alberto
Leite, Joao Pereira
author_sort Kandratavicius, Ludmyla
collection PubMed
description Epilepsy and psychiatric comorbidities are frequently associated, but their common biological substrate is unknown. We have previously reported altered structural elements and neurotrophins (NTs) expression in mesial temporal lobe epilepsy (MTLE) patients with psychiatric comorbidities. NTs receptors can regulate neurotransmission and promote neuroplasticity, being important candidates in the regulation and manifestation of psychopatological states and seizure-related events. MTLE hippocampi of subjects without psychiatric history, MTLE + major depression, MTLE + interictal psychosis derived from epilepsy surgery, and control necropsies were investigated for p75(NTR), TrkB, TrkA, and TrkC immunohistochemistry. Increased expression of p75(NTR), decreased TrkA, unaltered TrkC, and complex alterations involving TrkB expression were seen in MTLE groups. Increased TrkB expression in patients without complete seizure remission and in those with secondarily generalized seizures was seen. Decreased p75(NTR) expression associated with interictal psychosis, and increased TrkB in those with psychosis or major depression was also reported, although their p75(NTR)/TrkB ratios were lower than in MTLE without psychiatric comorbidities. Our results provide evidence of alterations in expression of NTs receptors in the epileptogenic hippocampus that are differentially modulated in presence of psychiatric comorbidities. As already explored in animal models, even in chronic human MTLE increased TrkB expression, among other NT receptors alterations, may play a major role in seizure type, frequency and surgery outcome.
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spelling pubmed-41491962014-08-30 Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome Kandratavicius, Ludmyla Hallak, Jaime Eduardo Carlotti, Carlos Gilberto Assirati, Joao Alberto Leite, Joao Pereira Acta Neuropathol Commun Research Epilepsy and psychiatric comorbidities are frequently associated, but their common biological substrate is unknown. We have previously reported altered structural elements and neurotrophins (NTs) expression in mesial temporal lobe epilepsy (MTLE) patients with psychiatric comorbidities. NTs receptors can regulate neurotransmission and promote neuroplasticity, being important candidates in the regulation and manifestation of psychopatological states and seizure-related events. MTLE hippocampi of subjects without psychiatric history, MTLE + major depression, MTLE + interictal psychosis derived from epilepsy surgery, and control necropsies were investigated for p75(NTR), TrkB, TrkA, and TrkC immunohistochemistry. Increased expression of p75(NTR), decreased TrkA, unaltered TrkC, and complex alterations involving TrkB expression were seen in MTLE groups. Increased TrkB expression in patients without complete seizure remission and in those with secondarily generalized seizures was seen. Decreased p75(NTR) expression associated with interictal psychosis, and increased TrkB in those with psychosis or major depression was also reported, although their p75(NTR)/TrkB ratios were lower than in MTLE without psychiatric comorbidities. Our results provide evidence of alterations in expression of NTs receptors in the epileptogenic hippocampus that are differentially modulated in presence of psychiatric comorbidities. As already explored in animal models, even in chronic human MTLE increased TrkB expression, among other NT receptors alterations, may play a major role in seizure type, frequency and surgery outcome. BioMed Central 2014-07-16 /pmc/articles/PMC4149196/ /pubmed/25027171 http://dx.doi.org/10.1186/s40478-014-0081-2 Text en © Kandratavicius et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Kandratavicius, Ludmyla
Hallak, Jaime Eduardo
Carlotti, Carlos Gilberto
Assirati, Joao Alberto
Leite, Joao Pereira
Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
title Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
title_full Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
title_fullStr Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
title_full_unstemmed Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
title_short Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
title_sort neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149196/
https://www.ncbi.nlm.nih.gov/pubmed/25027171
http://dx.doi.org/10.1186/s40478-014-0081-2
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