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Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
INTRODUCTION: It has been shown that progranulin (PGRN) deficiency causes age-related neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease. Previous studies also suggested that PGRN is involved in modulating...
Autores principales: | Tanaka, Yoshinori, Chambers, James K, Matsuwaki, Takashi, Yamanouchi, Keitaro, Nishihara, Masugi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149276/ https://www.ncbi.nlm.nih.gov/pubmed/25022663 http://dx.doi.org/10.1186/s40478-014-0078-x |
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