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Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study

Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations....

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Autores principales: Córdova-Palomera, Aldo, Alemany, Silvia, Fatjó-Vilas, Mar, Goldberg, Ximena, Leza, Juan Carlos, González-Pinto, Ana, Nenadic, Igor, Fañanás, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149354/
https://www.ncbi.nlm.nih.gov/pubmed/25171170
http://dx.doi.org/10.1371/journal.pone.0103639
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author Córdova-Palomera, Aldo
Alemany, Silvia
Fatjó-Vilas, Mar
Goldberg, Ximena
Leza, Juan Carlos
González-Pinto, Ana
Nenadic, Igor
Fañanás, Lourdes
author_facet Córdova-Palomera, Aldo
Alemany, Silvia
Fatjó-Vilas, Mar
Goldberg, Ximena
Leza, Juan Carlos
González-Pinto, Ana
Nenadic, Igor
Fañanás, Lourdes
author_sort Córdova-Palomera, Aldo
collection PubMed
description Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other.
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spelling pubmed-41493542014-09-03 Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study Córdova-Palomera, Aldo Alemany, Silvia Fatjó-Vilas, Mar Goldberg, Ximena Leza, Juan Carlos González-Pinto, Ana Nenadic, Igor Fañanás, Lourdes PLoS One Research Article Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other. Public Library of Science 2014-08-29 /pmc/articles/PMC4149354/ /pubmed/25171170 http://dx.doi.org/10.1371/journal.pone.0103639 Text en © 2014 Córdova-Palomera et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Córdova-Palomera, Aldo
Alemany, Silvia
Fatjó-Vilas, Mar
Goldberg, Ximena
Leza, Juan Carlos
González-Pinto, Ana
Nenadic, Igor
Fañanás, Lourdes
Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
title Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
title_full Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
title_fullStr Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
title_full_unstemmed Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
title_short Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
title_sort birth weight, working memory and epigenetic signatures in igf2 and related genes: a mz twin study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149354/
https://www.ncbi.nlm.nih.gov/pubmed/25171170
http://dx.doi.org/10.1371/journal.pone.0103639
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