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Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study
Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149354/ https://www.ncbi.nlm.nih.gov/pubmed/25171170 http://dx.doi.org/10.1371/journal.pone.0103639 |
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author | Córdova-Palomera, Aldo Alemany, Silvia Fatjó-Vilas, Mar Goldberg, Ximena Leza, Juan Carlos González-Pinto, Ana Nenadic, Igor Fañanás, Lourdes |
author_facet | Córdova-Palomera, Aldo Alemany, Silvia Fatjó-Vilas, Mar Goldberg, Ximena Leza, Juan Carlos González-Pinto, Ana Nenadic, Igor Fañanás, Lourdes |
author_sort | Córdova-Palomera, Aldo |
collection | PubMed |
description | Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other. |
format | Online Article Text |
id | pubmed-4149354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41493542014-09-03 Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study Córdova-Palomera, Aldo Alemany, Silvia Fatjó-Vilas, Mar Goldberg, Ximena Leza, Juan Carlos González-Pinto, Ana Nenadic, Igor Fañanás, Lourdes PLoS One Research Article Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other. Public Library of Science 2014-08-29 /pmc/articles/PMC4149354/ /pubmed/25171170 http://dx.doi.org/10.1371/journal.pone.0103639 Text en © 2014 Córdova-Palomera et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Córdova-Palomera, Aldo Alemany, Silvia Fatjó-Vilas, Mar Goldberg, Ximena Leza, Juan Carlos González-Pinto, Ana Nenadic, Igor Fañanás, Lourdes Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study |
title | Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study |
title_full | Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study |
title_fullStr | Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study |
title_full_unstemmed | Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study |
title_short | Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study |
title_sort | birth weight, working memory and epigenetic signatures in igf2 and related genes: a mz twin study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149354/ https://www.ncbi.nlm.nih.gov/pubmed/25171170 http://dx.doi.org/10.1371/journal.pone.0103639 |
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