Cargando…

Down-Regulation of 5-HT(1B) and 5-HT(1D) Receptors Inhibits Proliferation, Clonogenicity and Invasion of Human Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma is characterized by extensive local tumor invasion, metastasis and early systemic dissemination. The vast majority of pancreatic cancer (PaCa) patients already have metastatic complications at the time of diagnosis, and the death rate of this lethal type of cancer ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gurbuz, Nilgun, Ashour, Ahmed A., Alpay, S. Neslihan, Ozpolat, Bulent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149367/ https://www.ncbi.nlm.nih.gov/pubmed/25170871 http://dx.doi.org/10.1371/journal.pone.0105245

Ejemplares similares

Correction: Down-Regulation of 5-HT(1B) and 5-HT(1D) Receptors Inhibits Proliferation, Clonogenicity and Invasion of Human Pancreatic Cancer Cells
Publicado: (2014)

Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial–mesenchymal transition mediating pancreatic cancer cells invasion
por: Ashour, Ahmed A, et al.
Publicado: (2014)

Review: 5-HT(1), 5-HT(2), 5-HT(3) and 5-HT(7) Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
por: Cortes-Altamirano, Jose Luis, et al.
Publicado: (2018)

Conservation of 5-HT(1A) receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
por: Araragi, Naozumi, et al.
Publicado: (2013)

5-HT1A agonists, 5-HT3 antagonists and benzodiazepines : their comparative behavioural pharmacology /
Publicado: (1991)

Distribution of 5-HT(3), 5-HT(4), and 5-HT(7) Receptors Along the Human Colon
por: Yaakob, Nor S, et al.
Publicado: (2015)

5-HT(2A), 5-HT(1B/D), 5HT(3) and 5-HT(7) receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle
por: Da Costa Guevara, Darwin, et al.
Publicado: (2021)

5-HT(7) Receptor Contributes to Proliferation, Migration and Invasion in NSCLC Cells
por: Du, Xiaohui, et al.
Publicado: (2020)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development
por: Nikolić, Jelena, et al.
Publicado: (2023)

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT
por: Sia, Tiong C., et al.
Publicado: (2013)

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?
por: Spencer, Nick J.
Publicado: (2015)

Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications
por: Shahar, Orr, et al.
Publicado: (2022)

Role of peripheral 5-HT(5A) receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats
por: García-Pedraza, José Ángel, et al.
Publicado: (2020)

Effects of Acute MDMA Intoxication on Mood and Impulsivity: Role of the 5-HT(2) and 5-HT(1) Receptors
por: van Wel, Janelle H. P., et al.
Publicado: (2012)

Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

Human 5–HT(4) and 5–HT(7) Receptor Splice Variants: Are they Important?
por: Coupar, Ian M, et al.
Publicado: (2007)

Discriminating between 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, AJ, et al.
Publicado: (2013)

Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
por: Sengupta, Ayesha, et al.
Publicado: (2017)

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT(2A) and 5-HT(2B) receptors in chondrocytes
por: Hori, Ayaka, et al.
Publicado: (2017)

5-HT(3) Receptors
por: Lummis, Sarah C. R.
Publicado: (2012)

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR
por: Zilberg, Gregory, et al.
Publicado: (2023)

FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells
por: Hamurcu, Zuhal, et al.
Publicado: (2016)

5-HT and Intraplatelet 5-HT: a potential upstream regulator of YAP in liver regeneration
por: He, Chao, et al.
Publicado: (2019)

Deletion of Munc18-1 in 5-HT Neurons Results in Rapid Degeneration of the 5-HT System and Early Postnatal Lethality
por: Dudok, Jacobus J., et al.
Publicado: (2011)

Arterial expression of 5-HT(2B )and 5-HT(1B )receptors during development of DOCA-salt hypertension
por: Banes, Amy KL, et al.
Publicado: (2003)

Distinct Temporal Expression of 5-HT(1A) and 5-HT(2A) Receptors on Cerebellar Granule Cells in Mice
por: Oostland, Marlies, et al.
Publicado: (2014)

The role of the serotonin receptor subtypes 5-HT(1A) and 5-HT(7) and its interaction in emotional learning and memory
por: Stiedl, Oliver, et al.
Publicado: (2015)

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT(1A) and 5-HT(7) Antagonists in Animal Models
por: Pytka, Karolina, et al.
Publicado: (2015)

Pharmacological Characterization of 5-HT(1A) Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons
por: Montalbano, Alberto, et al.
Publicado: (2015)

Effects of 5-HT(2C), 5-HT(1A) receptor challenges and modafinil on the initiation and persistence of gambling behaviours
por: Humby, Trevor, et al.
Publicado: (2020)

5-HT(1A) and 5-HT(2B) receptor interaction and co-clustering regulate serotonergic neuron excitability
por: Benhadda, Amina, et al.
Publicado: (2023)

Targeted 5-HT(1F) Therapies for Migraine
por: Vila-Pueyo, Marta
Publicado: (2018)

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
por: Bell, Rob, et al.
Publicado: (2014)

Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors
por: Kori, S, et al.
Publicado: (2013)

Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain
por: Munawar, Neha, et al.
Publicado: (2023)

Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives
por: DELGERMURUN, Dugar, et al.
Publicado: (2015)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

Reduction of the serotonin 5-HT(1B) and 5-HT(2A) receptor-mediated contraction of human pulmonary artery by the combined 5-HT(1B) receptor antagonist and serotonin transporter inhibitor LY393558
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2020)

Peripheral 5-HT(1A) and 5-HT(7) Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats
por: Restrepo, Beatriz, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_tianeul20u9rc74fk8169qu15c