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Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
BACKGROUND: Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 (C9orf72) gene represent the most common genetic abnormality for familial and sporadic amyotrophic lateral sclerosis (ALS) and f...
Autores principales: | Satoh, Jun-ichi, Yamamoto, Yoji, Kitano, Shouta, Takitani, Mika, Asahina, Naohiro, Kino, Yoshihiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149381/ https://www.ncbi.nlm.nih.gov/pubmed/25210488 http://dx.doi.org/10.4137/JCNSD.S18103 |
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