Cargando…

Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus

Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been...

Descripción completa

Detalles Bibliográficos
Autores principales: Tuppurainen, Eeva S.M., Pearson, Caroline R., Bachanek-Bankowska, Katarzyna, Knowles, Nick J., Amareen, Shadi, Frost, Lorraine, Henstock, Mark R., Lamien, Charles E., Diallo, Adama, Mertens, Peter P.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149609/
https://www.ncbi.nlm.nih.gov/pubmed/24973760
http://dx.doi.org/10.1016/j.antiviral.2014.06.009
_version_ 1782332791085596672
author Tuppurainen, Eeva S.M.
Pearson, Caroline R.
Bachanek-Bankowska, Katarzyna
Knowles, Nick J.
Amareen, Shadi
Frost, Lorraine
Henstock, Mark R.
Lamien, Charles E.
Diallo, Adama
Mertens, Peter P.C.
author_facet Tuppurainen, Eeva S.M.
Pearson, Caroline R.
Bachanek-Bankowska, Katarzyna
Knowles, Nick J.
Amareen, Shadi
Frost, Lorraine
Henstock, Mark R.
Lamien, Charles E.
Diallo, Adama
Mertens, Peter P.C.
author_sort Tuppurainen, Eeva S.M.
collection PubMed
description Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for cattle against lumpy skin disease virus (LSDV). In the Middle East and the Horn of Africa these vaccines have been associated with incomplete protection and adverse reactions in cattle post-vaccination. The present study confirms that the real identity of the commonly used Kenyan sheep and goat pox vaccine virus (KSGP) O-240 is not SPPV but is actually LSDV. The low level attenuation of this virus is likely to be not sufficient for safe use in cattle, causing clinical disease in vaccinated animals. In addition, Isiolo and Kedong goat pox strains, capable of infecting sheep, goats and cattle are identified for potential use as broad-spectrum vaccine candidates against all capripox diseases.
format Online
Article
Text
id pubmed-4149609
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-41496092014-09-01 Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus Tuppurainen, Eeva S.M. Pearson, Caroline R. Bachanek-Bankowska, Katarzyna Knowles, Nick J. Amareen, Shadi Frost, Lorraine Henstock, Mark R. Lamien, Charles E. Diallo, Adama Mertens, Peter P.C. Antiviral Res Article Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for cattle against lumpy skin disease virus (LSDV). In the Middle East and the Horn of Africa these vaccines have been associated with incomplete protection and adverse reactions in cattle post-vaccination. The present study confirms that the real identity of the commonly used Kenyan sheep and goat pox vaccine virus (KSGP) O-240 is not SPPV but is actually LSDV. The low level attenuation of this virus is likely to be not sufficient for safe use in cattle, causing clinical disease in vaccinated animals. In addition, Isiolo and Kedong goat pox strains, capable of infecting sheep, goats and cattle are identified for potential use as broad-spectrum vaccine candidates against all capripox diseases. Elsevier 2014-09 /pmc/articles/PMC4149609/ /pubmed/24973760 http://dx.doi.org/10.1016/j.antiviral.2014.06.009 Text en Crown Copyright © 2014 Published by Elsevier B.V. All rights reserved. https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Tuppurainen, Eeva S.M.
Pearson, Caroline R.
Bachanek-Bankowska, Katarzyna
Knowles, Nick J.
Amareen, Shadi
Frost, Lorraine
Henstock, Mark R.
Lamien, Charles E.
Diallo, Adama
Mertens, Peter P.C.
Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
title Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
title_full Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
title_fullStr Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
title_full_unstemmed Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
title_short Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
title_sort characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149609/
https://www.ncbi.nlm.nih.gov/pubmed/24973760
http://dx.doi.org/10.1016/j.antiviral.2014.06.009
work_keys_str_mv AT tuppuraineneevasm characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT pearsoncaroliner characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT bachanekbankowskakatarzyna characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT knowlesnickj characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT amareenshadi characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT frostlorraine characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT henstockmarkr characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT lamiencharlese characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT dialloadama characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus
AT mertenspeterpc characterizationofsheeppoxvirusvaccineforcattleagainstlumpyskindiseasevirus