115 Immune Correlates of Protection in Rhesus Monkeys

We have previously reported the protective efficacy of Ad26/MVA vector regimens expressing SIVsmE543 Env/Gag/Pol antigens against SIVmac251 challenge. Here we assess the potential utility of adding a protein trimer boost to adenovirus based vaccine regimens. We produced stable SIV and HIV Env gp140...

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Detalles Bibliográficos
Autor principal: Barouch, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2014
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149648/
http://dx.doi.org/10.1097/01.qai.0000446695.85033.26
Descripción
Sumario:We have previously reported the protective efficacy of Ad26/MVA vector regimens expressing SIVsmE543 Env/Gag/Pol antigens against SIVmac251 challenge. Here we assess the potential utility of adding a protein trimer boost to adenovirus based vaccine regimens. We produced stable SIV and HIV Env gp140 trimers and assessed the immunogenicity and protective efficacy of Ad prime, Env gp140 trimer boost regimens against SIVmac251 and SHIV-SF162P3 challenges in rhesus monkeys. Vector prime, protein boost vaccine regimens induced higher titer binding and neutralizing antibodies compared with protein only regimens. Clinical studies to evaluate Ad26/MVA and Ad26/protein vaccine regimens are planned.

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