Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent

(166)Holmium-1,2-propylene di-amino tetra (methy1enephosphonicacid) ((166) Ho-PDTMP) complex was prepared successfully using an in-house synthesized PDTMP ligand and (166) HoCl (3) . Ho-166 chloride was obtained by thermal neutron irradiation (1 × 10 (13) n/cm (2) /s) of natural Ho (NO (3) ) (3) sam...

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Autores principales: Zolghadri, Samaneh, Jalilian, Amir Reza, Yousefnia, Hassan, Bahrami-Samani, Ali, Ghannadi-Maragheh, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149765/
https://www.ncbi.nlm.nih.gov/pubmed/25191109
http://dx.doi.org/10.4103/1450-1147.138571
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author Zolghadri, Samaneh
Jalilian, Amir Reza
Yousefnia, Hassan
Bahrami-Samani, Ali
Ghannadi-Maragheh, Mohammad
author_facet Zolghadri, Samaneh
Jalilian, Amir Reza
Yousefnia, Hassan
Bahrami-Samani, Ali
Ghannadi-Maragheh, Mohammad
author_sort Zolghadri, Samaneh
collection PubMed
description (166)Holmium-1,2-propylene di-amino tetra (methy1enephosphonicacid) ((166) Ho-PDTMP) complex was prepared successfully using an in-house synthesized PDTMP ligand and (166) HoCl (3) . Ho-166 chloride was obtained by thermal neutron irradiation (1 × 10 (13) n/cm (2) /s) of natural Ho (NO (3) ) (3) samples (specific activity = 3-5 GBq/mg), dissolved in acidic media. Radiochemical purity of (166) Ho-PDTMP was checked by instant thin layer chromatography (>99%). Stability studies of the complex in the final preparation and in the presence of human serum were performed up to 72 h. The biodistribution of (166) Ho-PDTMP and (166) HoCl (3) in wild-type rats was checked in animal tissues up to 48 h. The produced (166) Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.
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spelling pubmed-41497652014-09-04 Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent Zolghadri, Samaneh Jalilian, Amir Reza Yousefnia, Hassan Bahrami-Samani, Ali Ghannadi-Maragheh, Mohammad World J Nucl Med Original Article (166)Holmium-1,2-propylene di-amino tetra (methy1enephosphonicacid) ((166) Ho-PDTMP) complex was prepared successfully using an in-house synthesized PDTMP ligand and (166) HoCl (3) . Ho-166 chloride was obtained by thermal neutron irradiation (1 × 10 (13) n/cm (2) /s) of natural Ho (NO (3) ) (3) samples (specific activity = 3-5 GBq/mg), dissolved in acidic media. Radiochemical purity of (166) Ho-PDTMP was checked by instant thin layer chromatography (>99%). Stability studies of the complex in the final preparation and in the presence of human serum were performed up to 72 h. The biodistribution of (166) Ho-PDTMP and (166) HoCl (3) in wild-type rats was checked in animal tissues up to 48 h. The produced (166) Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4149765/ /pubmed/25191109 http://dx.doi.org/10.4103/1450-1147.138571 Text en Copyright: © World Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zolghadri, Samaneh
Jalilian, Amir Reza
Yousefnia, Hassan
Bahrami-Samani, Ali
Ghannadi-Maragheh, Mohammad
Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent
title Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent
title_full Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent
title_fullStr Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent
title_full_unstemmed Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent
title_short Development of (166)Holmium-1,2 Propylene Di-amino Tetra (Methy1enephosphonicacid) as a Possible Bone Palliation Agent
title_sort development of (166)holmium-1,2 propylene di-amino tetra (methy1enephosphonicacid) as a possible bone palliation agent
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149765/
https://www.ncbi.nlm.nih.gov/pubmed/25191109
http://dx.doi.org/10.4103/1450-1147.138571
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