Lack of recombinant factor VIII B-domain induces phospholipid vesicle aggregation: implications for the immunogenicity of factor VIII

Factor VIII (FVIII) is a multidomain blood plasma glycoprotein. Activated FVIII acts as a cofactor to the serine protease factor IXa within the membrane-bound tenase complex assembled on the activated platelet surface. Defect or deficiency in FVIII causes haemophilia A, a severe hereditary bleeding...

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Detalles Bibliográficos
Autores principales: Grushin, K, Miller, J, Dalm, D, Parker, E T, Healey, J F, Lollar, P, Stoilova-McPhie, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149818/
https://www.ncbi.nlm.nih.gov/pubmed/24750465
http://dx.doi.org/10.1111/hae.12421

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