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End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study

STUDY DESIGN: Case-control. PURPOSE: To determine whether a disproportion between two neighboring vertebral end plates is associated with degenerative disc disease. OVERVIEW OF LITERATURE: Recently, it has been suggested that disproportion of the end plates of two adjacent vertebrae may increase the...

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Autores principales: Poureisa, Masoud, Daghighi, Mohammad Hossein, Mesbahi, Sepideh, Hagigi, Amir, Fouladi, Daniel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Spine Surgery 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149982/
https://www.ncbi.nlm.nih.gov/pubmed/25187856
http://dx.doi.org/10.4184/asj.2014.8.4.405
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author Poureisa, Masoud
Daghighi, Mohammad Hossein
Mesbahi, Sepideh
Hagigi, Amir
Fouladi, Daniel F
author_facet Poureisa, Masoud
Daghighi, Mohammad Hossein
Mesbahi, Sepideh
Hagigi, Amir
Fouladi, Daniel F
author_sort Poureisa, Masoud
collection PubMed
description STUDY DESIGN: Case-control. PURPOSE: To determine whether a disproportion between two neighboring vertebral end plates is associated with degenerative disc disease. OVERVIEW OF LITERATURE: Recently, it has been suggested that disproportion of the end plates of two adjacent vertebrae may increase the risk of disc herniation. METHODS: Magnetic resonance (MR) images (n=160) with evidence of grades I-II lumbar degenerative disc disease (modified Pfirrmann's classification) and normal MR images of the lumbar region (n=160) were reviewed. On midsagittal sections, the difference of anteroposterior diameter of upper and lower end plates neighboring a degenerated (in the case group) or normal (in the control group) intervertebral disc was calculated (difference of end plates [DEP]). RESULTS: Mean DEP was significantly higher in the case group at the L5-S1 level (2.73±0.23 mm vs. 2.21±0.12 mm, p=0.03). Differences were not statistically significant at L1-L2 (1.31±0.13 mm in the cases vs. 1.28±0.08 mm in the controls, p=0.78), L2-L3 (1.45±0.12 mm in the cases vs. 1.37±0.08 mm in the controls, p=0.58), L3-L4 (1.52±0.13 mm in the cases vs. 1.49±0.10 mm in the controls, p=0.88), and L4-L5 (2.15±0.21 mm in the cases vs. 2.04±0.20 mm in the controls, p=0.31) levels. The difference at the L5-S1 level did not remain significant after adjusting for body mass index (BMI), which was significantly higher in the patients. CONCLUSIONS: End plate disproportion may be a significant, BMI-dependent risk factor for lumbar degenerative disc disease.
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spelling pubmed-41499822014-09-03 End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study Poureisa, Masoud Daghighi, Mohammad Hossein Mesbahi, Sepideh Hagigi, Amir Fouladi, Daniel F Asian Spine J Clinical Study STUDY DESIGN: Case-control. PURPOSE: To determine whether a disproportion between two neighboring vertebral end plates is associated with degenerative disc disease. OVERVIEW OF LITERATURE: Recently, it has been suggested that disproportion of the end plates of two adjacent vertebrae may increase the risk of disc herniation. METHODS: Magnetic resonance (MR) images (n=160) with evidence of grades I-II lumbar degenerative disc disease (modified Pfirrmann's classification) and normal MR images of the lumbar region (n=160) were reviewed. On midsagittal sections, the difference of anteroposterior diameter of upper and lower end plates neighboring a degenerated (in the case group) or normal (in the control group) intervertebral disc was calculated (difference of end plates [DEP]). RESULTS: Mean DEP was significantly higher in the case group at the L5-S1 level (2.73±0.23 mm vs. 2.21±0.12 mm, p=0.03). Differences were not statistically significant at L1-L2 (1.31±0.13 mm in the cases vs. 1.28±0.08 mm in the controls, p=0.78), L2-L3 (1.45±0.12 mm in the cases vs. 1.37±0.08 mm in the controls, p=0.58), L3-L4 (1.52±0.13 mm in the cases vs. 1.49±0.10 mm in the controls, p=0.88), and L4-L5 (2.15±0.21 mm in the cases vs. 2.04±0.20 mm in the controls, p=0.31) levels. The difference at the L5-S1 level did not remain significant after adjusting for body mass index (BMI), which was significantly higher in the patients. CONCLUSIONS: End plate disproportion may be a significant, BMI-dependent risk factor for lumbar degenerative disc disease. Korean Society of Spine Surgery 2014-08 2014-08-19 /pmc/articles/PMC4149982/ /pubmed/25187856 http://dx.doi.org/10.4184/asj.2014.8.4.405 Text en Copyright © 2014 by Korean Society of Spine Surgery http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Poureisa, Masoud
Daghighi, Mohammad Hossein
Mesbahi, Sepideh
Hagigi, Amir
Fouladi, Daniel F
End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study
title End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study
title_full End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study
title_fullStr End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study
title_full_unstemmed End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study
title_short End Plate Disproportion and Degenerative Disc Disease: A Case-Control Study
title_sort end plate disproportion and degenerative disc disease: a case-control study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149982/
https://www.ncbi.nlm.nih.gov/pubmed/25187856
http://dx.doi.org/10.4184/asj.2014.8.4.405
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