Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies

The human immunodeficiency virus type-1 (HIV-1) genome contains multiple, highly conserved structural RNA domains that play key roles in essential viral processes. Interference with the function of these RNA domains either by disrupting their structures or by blocking their interaction with viral or...

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Detalles Bibliográficos
Autores principales: Sánchez-Luque, Francisco J., Stich, Michael, Manrubia, Susanna, Briones, Carlos, Berzal-Herranz, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150108/
https://www.ncbi.nlm.nih.gov/pubmed/25175101
http://dx.doi.org/10.1038/srep06242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150108/
https://www.ncbi.nlm.nih.gov/pubmed/25175101
http://dx.doi.org/10.1038/srep06242

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