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Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies
The human immunodeficiency virus type-1 (HIV-1) genome contains multiple, highly conserved structural RNA domains that play key roles in essential viral processes. Interference with the function of these RNA domains either by disrupting their structures or by blocking their interaction with viral or...
Autores principales: | Sánchez-Luque, Francisco J., Stich, Michael, Manrubia, Susanna, Briones, Carlos, Berzal-Herranz, Alfredo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150108/ https://www.ncbi.nlm.nih.gov/pubmed/25175101 http://dx.doi.org/10.1038/srep06242 |
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