Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report

This case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. Immunoblotting analysis reactivity against Histoplasma capsulatum and Paracoccidioides brasiliensis were observed. Nested-PCR in blood employing species-specific primers was positive for...

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Autores principales: Dantas, Kátia Cristina, de Freitas, Roseli Santos, Garcia, Roberta Scholz Pinto, da Silva, Marcos Vinícius, Muricy, Edna Cleide Mendes, Kohara, Valdelene Sayuri, Vicentini, Adriana Pardini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150115/
https://www.ncbi.nlm.nih.gov/pubmed/25180029
http://dx.doi.org/10.1186/1678-9199-20-36
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author Dantas, Kátia Cristina
de Freitas, Roseli Santos
Garcia, Roberta Scholz Pinto
da Silva, Marcos Vinícius
Muricy, Edna Cleide Mendes
Kohara, Valdelene Sayuri
Vicentini, Adriana Pardini
author_facet Dantas, Kátia Cristina
de Freitas, Roseli Santos
Garcia, Roberta Scholz Pinto
da Silva, Marcos Vinícius
Muricy, Edna Cleide Mendes
Kohara, Valdelene Sayuri
Vicentini, Adriana Pardini
author_sort Dantas, Kátia Cristina
collection PubMed
description This case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. Immunoblotting analysis reactivity against Histoplasma capsulatum and Paracoccidioides brasiliensis were observed. Nested-PCR in blood employing species-specific primers was positive for H. capsulatum and Cryptococcus neoformans. The evaluation of paucisymptomatic patients with positive results for H. capsulatum and C. neoformans could be relevant for the prevention as well as the possible evaluation of the reactivated quiescent foci. In conclusion, the associated methodology may have contributed to the monitoring endogenous reactivation of these diseases.
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spelling pubmed-41501152014-09-02 Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report Dantas, Kátia Cristina de Freitas, Roseli Santos Garcia, Roberta Scholz Pinto da Silva, Marcos Vinícius Muricy, Edna Cleide Mendes Kohara, Valdelene Sayuri Vicentini, Adriana Pardini J Venom Anim Toxins Incl Trop Dis Case Report This case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. Immunoblotting analysis reactivity against Histoplasma capsulatum and Paracoccidioides brasiliensis were observed. Nested-PCR in blood employing species-specific primers was positive for H. capsulatum and Cryptococcus neoformans. The evaluation of paucisymptomatic patients with positive results for H. capsulatum and C. neoformans could be relevant for the prevention as well as the possible evaluation of the reactivated quiescent foci. In conclusion, the associated methodology may have contributed to the monitoring endogenous reactivation of these diseases. BioMed Central 2014-08-26 /pmc/articles/PMC4150115/ /pubmed/25180029 http://dx.doi.org/10.1186/1678-9199-20-36 Text en Copyright © 2014 Dantas et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Dantas, Kátia Cristina
de Freitas, Roseli Santos
Garcia, Roberta Scholz Pinto
da Silva, Marcos Vinícius
Muricy, Edna Cleide Mendes
Kohara, Valdelene Sayuri
Vicentini, Adriana Pardini
Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report
title Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report
title_full Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report
title_fullStr Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report
title_full_unstemmed Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report
title_short Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report
title_sort importance of the association of molecular and immunological diagnosis in immunocompetent patient with histoplasma capsulatum and cryptoccocus neoformans infection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150115/
https://www.ncbi.nlm.nih.gov/pubmed/25180029
http://dx.doi.org/10.1186/1678-9199-20-36
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