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Nuclear envelope protein MAN1 regulates clock through BMAL1

Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks of feedback loops that fine-tune circadian processes. Our knowledge of these components and pathway...

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Detalles Bibliográficos
Autores principales: Lin, Shu-Ting, Zhang, Luoying, Lin, Xiaoyan, Zhang, Linda Chen, Garcia, Valentina Elizabeth, Tsai, Chen-Wei, Ptáček, Louis, Fu, Ying-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150126/
https://www.ncbi.nlm.nih.gov/pubmed/25182847
http://dx.doi.org/10.7554/eLife.02981
Descripción
Sumario:Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks of feedback loops that fine-tune circadian processes. Our knowledge of these components and pathways is far from exhaustive. In recent decades, the nuclear envelope has emerged as a global gene regulatory machine, although its role in circadian regulation has not been explored. We report that transcription of the core clock component BMAL1 is positively modulated by the inner nuclear membrane protein MAN1, which directly binds the BMAL1 promoter and enhances its transcription. Our results establish a novel connection between the nuclear periphery and circadian rhythmicity, therefore bridging two global regulatory systems that modulate all aspects of bodily functions. DOI: http://dx.doi.org/10.7554/eLife.02981.001