Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours

BACKGROUND: The binding of STAT3 and STAT5 to growth factor and cytokine receptors such as EGFR and IL-6 receptor gp130 is critical to their activation and ability to contribute to malignant transformation. Therefore, interfering with these biochemical processes could lead to the discovery of novel...

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Detalles Bibliográficos
Autores principales: Zhang, X, Blaskovich, M A, Forinash, K D, Sebti, S M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150266/
https://www.ncbi.nlm.nih.gov/pubmed/24983364
http://dx.doi.org/10.1038/bjc.2014.349

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