Cargando…

Validation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail

BACKGROUND: Predictive biomarker development is a key challenge for novel cancer therapeutics. We explored the feasibility of next-generation sequencing (NGS) to validate exploratory genomic biomarkers that impact phase I trial selection. METHODS: We prospectively enrolled 158 patients with advanced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ong, M, Carreira, S, Goodall, J, Mateo, J, Figueiredo, I, Rodrigues, D N, Perkins, G, Seed, G, Yap, T A, Attard, G, de Bono, J S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150267/ https://www.ncbi.nlm.nih.gov/pubmed/24983367 http://dx.doi.org/10.1038/bjc.2014.350

Ejemplares similares

Analysis of the quality of hospital information systems audit trails
por: Cruz-Correia, Ricardo, et al.
Publicado: (2013)

Acquiring evidence for precision prostate cancer care
por: Mateo, J., et al.
Publicado: (2017)

Trail Conditions and Community Use: Utilizing Geospatial Video to Guide the Adoption of a Spatial-Temporal Trail Audit Tool (STAT)
por: Smock, Carissa, et al.
Publicado: (2021)

Cohort Profile Update: The TRacking Adolescents’ Individual Lives Survey—The Next Generation (TRAILS NEXT)
por: Hartman, Catharina A, et al.
Publicado: (2022)

Audit of the impact of the integrated psychological medicine service (IPMS) on service utilisation
por: Harvey, Sarah, et al.
Publicado: (2021)

Pattern of outpatient utilisation and cost for patients under the Universal Coverage
por: Sumputtanon, Kanet, et al.
Publicado: (2014)

A Systematic Review of Utilisation of Diurnal Timing Information in Clinical Trial Design for Long QT Syndrome
por: Seed, Lydia M., et al.
Publicado: (2022)

MSC-Delivered Soluble TRAIL and Paclitaxel as Novel Combinatory Treatment for Pancreatic Adenocarcinoma
por: Rossignoli, Filippo, et al.
Publicado: (2019)

Oxaliplatin Enhances the Apoptotic Effect of Mesenchymal Stem Cells, Delivering Soluble TRAIL in Chemoresistant Colorectal Cancer
por: Quiroz-Reyes, Adriana G, et al.
Publicado: (2023)

Implementing an audit and feedback cycle to improve adherence to the Choosing Wisely Canada recommendations: clustered randomized trail
por: Singer, Alexander, et al.
Publicado: (2022)

Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer
por: Pezaro, C, et al.
Publicado: (2013)

5612984 AUDIT OF TRUST COMPLIANCE WITH BSH GUIDELINES FOR UTILISATION OF HYDROXYCARBAMIDE IN PATIENTS WITH SICKLE CELL DISEASE
por: Barker, R., et al.
Publicado: (2023)

Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
por: Pereira, Dora I.A., et al.
Publicado: (2014)

Auditing the value of empirical audits
por: Lynch, John G., et al.
Publicado: (2023)

Universal health coverage: time to deliver on political promises
por: Tangcharoensathien, Viroj, et al.
Publicado: (2020)

Environmental perceptions and objective walking trail audits inform a community-based participatory research walking intervention
por: Zoellner, Jamie, et al.
Publicado: (2012)

Malaria in Macedonia: A Clinical Lecture Delivered in the Royal Infirmary
por: Goodall, Alexander
Publicado: (1919)

A 6-year audit of public-sector MR utilisation in the Western Cape province of South Africa
por: Parak, Yusuf, et al.
Publicado: (2022)

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells
por: Trivedi, Rachana, et al.
Publicado: (2015)

Maternal health services utilisation among primigravidas in Uganda: what did the MDGs deliver?
por: Atuoye, Kilian Nasung, et al.
Publicado: (2020)

The Management of Acute Myocardial Infarction: Guidelines and Audit Standards: Report of a Workshop of the Joint Audit Committee of the British Cardiac Society and the Royal College of Physicians
por: De Bono, D P, et al.
Publicado: (1994)

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family
por: Degli-Esposti, Mariapia A., et al.
Publicado: (1997)

Utilisation du varilog
por: Métral, G
Publicado: (1995)

Effective machine-learning assembly for next-generation amplicon sequencing with very low coverage
por: Ranjard, Louis, et al.
Publicado: (2019)

National Audit of Seizure management in Hospitals (NASH): results of the national audit of adult epilepsy in the UK
por: Dixon, Peter A, et al.
Publicado: (2015)

Improving the outcome of patients with castration-resistant prostate cancer through rational drug development
por: Attard, G, et al.
Publicado: (2006)

Comparative Quantification of Trail-Following Behavior in Pest Ants
por: Vázquez, Ricardo J., et al.
Publicado: (2019)

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL
por: Meijer, A, et al.
Publicado: (2013)

The Development and Testing of a Cardiac Rehabilitation Audit Tool
por: Thompson, David R, et al.
Publicado: (1997)

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis
por: Estornes, Yann, et al.
Publicado: (2018)

Overcoming distrust to deliver universal health coverage: lessons from Ebola
por: Woskie, Liana R, et al.
Publicado: (2019)

Correction to: Effective machine-learning assembly for next-generation amplicon sequencing with very low coverage
por: Ranjard, Louis, et al.
Publicado: (2020)

Hot on the Trail of TRP Channel Structure
por: Moiseenkova-Bell, Vera Y., et al.
Publicado: (2009)

Evaluating the Coverage and Potential of Imputing the Exome Microarray with Next-Generation Imputation Using the 1000 Genomes Project
por: Tantoso, Erwin, et al.
Publicado: (2014)

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing
por: Simon, Michelle M., et al.
Publicado: (2015)

Equity of Health Services Utilisation and Expenditure among Urban and Rural Residents under Universal Health Coverage
por: Xu, Jianqiang, et al.
Publicado: (2021)

TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis
por: López-Gómez, Carlos, et al.
Publicado: (2011)

TRAIL combinations: The new ‘trail’ for cancer therapy (Review)
por: REFAAT, ALAA, et al.
Publicado: (2014)

A Viral Discovery Methodology for Clinical Biopsy Samples Utilising Massively Parallel Next Generation Sequencing
por: Daly, Gordon M., et al.
Publicado: (2011)

Evaluating coverage bias in next-generation sequencing of Escherichia coli
por: Gunasekera, Samantha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jhkn84tohp16qekq45tusrceai