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Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150429/ https://www.ncbi.nlm.nih.gov/pubmed/25202337 http://dx.doi.org/10.1155/2014/825181 |
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author | Cao, Peng-Chong Xiao, Wen-Xing Yan, Ya-Bo Zhao, Xiong Liu, Shuai Feng, Jing Zhang, Wei Wang, Jun Feng, Ya-Fei Lei, Wei |
author_facet | Cao, Peng-Chong Xiao, Wen-Xing Yan, Ya-Bo Zhao, Xiong Liu, Shuai Feng, Jing Zhang, Wei Wang, Jun Feng, Ya-Fei Lei, Wei |
author_sort | Cao, Peng-Chong |
collection | PubMed |
description | The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E (2), 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day). Daily oral administration of E (2) or crocin started 4 weeks after OVX and lasted for 16 weeks. Our results showed that crocin dose-dependently inhibited the BMD reduction of L4 vertebrae and femurs caused by OVX and prevented the deterioration of trabecular microarchitecture, which were accompanied by a significant decrease in skeletal remodeling as evidenced by the lower levels of bone turnover markers. Furthermore, crocin reversed the oxidative stress status in both serum and bone tissue. The present study indicates that the administration of crocin at higher doses over a 16-week period can prevent OVX-induced osteoporosis in rats without hyperplastic effects on the uterus, which may, at least partially, be attributed to crocin's antioxidative property. In brief, crocin is a natural alternative for postmenopausal osteoporosis treatment in elderly women. |
format | Online Article Text |
id | pubmed-4150429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41504292014-09-08 Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model Cao, Peng-Chong Xiao, Wen-Xing Yan, Ya-Bo Zhao, Xiong Liu, Shuai Feng, Jing Zhang, Wei Wang, Jun Feng, Ya-Fei Lei, Wei Evid Based Complement Alternat Med Research Article The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E (2), 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day). Daily oral administration of E (2) or crocin started 4 weeks after OVX and lasted for 16 weeks. Our results showed that crocin dose-dependently inhibited the BMD reduction of L4 vertebrae and femurs caused by OVX and prevented the deterioration of trabecular microarchitecture, which were accompanied by a significant decrease in skeletal remodeling as evidenced by the lower levels of bone turnover markers. Furthermore, crocin reversed the oxidative stress status in both serum and bone tissue. The present study indicates that the administration of crocin at higher doses over a 16-week period can prevent OVX-induced osteoporosis in rats without hyperplastic effects on the uterus, which may, at least partially, be attributed to crocin's antioxidative property. In brief, crocin is a natural alternative for postmenopausal osteoporosis treatment in elderly women. Hindawi Publishing Corporation 2014 2014-08-14 /pmc/articles/PMC4150429/ /pubmed/25202337 http://dx.doi.org/10.1155/2014/825181 Text en Copyright © 2014 Peng-Chong Cao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cao, Peng-Chong Xiao, Wen-Xing Yan, Ya-Bo Zhao, Xiong Liu, Shuai Feng, Jing Zhang, Wei Wang, Jun Feng, Ya-Fei Lei, Wei Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model |
title | Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model |
title_full | Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model |
title_fullStr | Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model |
title_full_unstemmed | Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model |
title_short | Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model |
title_sort | preventive effect of crocin on osteoporosis in an ovariectomized rat model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150429/ https://www.ncbi.nlm.nih.gov/pubmed/25202337 http://dx.doi.org/10.1155/2014/825181 |
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