Cargando…

Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model

The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Peng-Chong, Xiao, Wen-Xing, Yan, Ya-Bo, Zhao, Xiong, Liu, Shuai, Feng, Jing, Zhang, Wei, Wang, Jun, Feng, Ya-Fei, Lei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150429/
https://www.ncbi.nlm.nih.gov/pubmed/25202337
http://dx.doi.org/10.1155/2014/825181
_version_ 1782332893585997824
author Cao, Peng-Chong
Xiao, Wen-Xing
Yan, Ya-Bo
Zhao, Xiong
Liu, Shuai
Feng, Jing
Zhang, Wei
Wang, Jun
Feng, Ya-Fei
Lei, Wei
author_facet Cao, Peng-Chong
Xiao, Wen-Xing
Yan, Ya-Bo
Zhao, Xiong
Liu, Shuai
Feng, Jing
Zhang, Wei
Wang, Jun
Feng, Ya-Fei
Lei, Wei
author_sort Cao, Peng-Chong
collection PubMed
description The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E (2), 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day). Daily oral administration of E (2) or crocin started 4 weeks after OVX and lasted for 16 weeks. Our results showed that crocin dose-dependently inhibited the BMD reduction of L4 vertebrae and femurs caused by OVX and prevented the deterioration of trabecular microarchitecture, which were accompanied by a significant decrease in skeletal remodeling as evidenced by the lower levels of bone turnover markers. Furthermore, crocin reversed the oxidative stress status in both serum and bone tissue. The present study indicates that the administration of crocin at higher doses over a 16-week period can prevent OVX-induced osteoporosis in rats without hyperplastic effects on the uterus, which may, at least partially, be attributed to crocin's antioxidative property. In brief, crocin is a natural alternative for postmenopausal osteoporosis treatment in elderly women.
format Online
Article
Text
id pubmed-4150429
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41504292014-09-08 Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model Cao, Peng-Chong Xiao, Wen-Xing Yan, Ya-Bo Zhao, Xiong Liu, Shuai Feng, Jing Zhang, Wei Wang, Jun Feng, Ya-Fei Lei, Wei Evid Based Complement Alternat Med Research Article The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E (2), 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day). Daily oral administration of E (2) or crocin started 4 weeks after OVX and lasted for 16 weeks. Our results showed that crocin dose-dependently inhibited the BMD reduction of L4 vertebrae and femurs caused by OVX and prevented the deterioration of trabecular microarchitecture, which were accompanied by a significant decrease in skeletal remodeling as evidenced by the lower levels of bone turnover markers. Furthermore, crocin reversed the oxidative stress status in both serum and bone tissue. The present study indicates that the administration of crocin at higher doses over a 16-week period can prevent OVX-induced osteoporosis in rats without hyperplastic effects on the uterus, which may, at least partially, be attributed to crocin's antioxidative property. In brief, crocin is a natural alternative for postmenopausal osteoporosis treatment in elderly women. Hindawi Publishing Corporation 2014 2014-08-14 /pmc/articles/PMC4150429/ /pubmed/25202337 http://dx.doi.org/10.1155/2014/825181 Text en Copyright © 2014 Peng-Chong Cao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cao, Peng-Chong
Xiao, Wen-Xing
Yan, Ya-Bo
Zhao, Xiong
Liu, Shuai
Feng, Jing
Zhang, Wei
Wang, Jun
Feng, Ya-Fei
Lei, Wei
Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
title Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
title_full Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
title_fullStr Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
title_full_unstemmed Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
title_short Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
title_sort preventive effect of crocin on osteoporosis in an ovariectomized rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150429/
https://www.ncbi.nlm.nih.gov/pubmed/25202337
http://dx.doi.org/10.1155/2014/825181
work_keys_str_mv AT caopengchong preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT xiaowenxing preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT yanyabo preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT zhaoxiong preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT liushuai preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT fengjing preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT zhangwei preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT wangjun preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT fengyafei preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel
AT leiwei preventiveeffectofcrocinonosteoporosisinanovariectomizedratmodel