Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()

Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case...

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Detalles Bibliográficos
Autores principales: Kaufman, Kenneth R., Velez, Arnaldo E., Wong, Stephen, Mani, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150593/
https://www.ncbi.nlm.nih.gov/pubmed/25688049
http://dx.doi.org/10.1016/j.ebcr.2012.10.006
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author Kaufman, Kenneth R.
Velez, Arnaldo E.
Wong, Stephen
Mani, Ram
author_facet Kaufman, Kenneth R.
Velez, Arnaldo E.
Wong, Stephen
Mani, Ram
author_sort Kaufman, Kenneth R.
collection PubMed
description Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case represents the first instance of LCM-induced atrial fibrillation following a low loading dose (200 mg). Risk factors for atrial fibrillation are addressed and discussed in the context of this case. Full cardiac history is recommended prior to patients being initiated on LCM. Cardiac monitoring may be required for at-risk patients on LCM. Clinicians need to be cognizant of this potential adverse effect.
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spelling pubmed-41505932015-02-09 Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()() Kaufman, Kenneth R. Velez, Arnaldo E. Wong, Stephen Mani, Ram Epilepsy Behav Case Rep Case Report Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case represents the first instance of LCM-induced atrial fibrillation following a low loading dose (200 mg). Risk factors for atrial fibrillation are addressed and discussed in the context of this case. Full cardiac history is recommended prior to patients being initiated on LCM. Cardiac monitoring may be required for at-risk patients on LCM. Clinicians need to be cognizant of this potential adverse effect. Elsevier 2012-11-08 /pmc/articles/PMC4150593/ /pubmed/25688049 http://dx.doi.org/10.1016/j.ebcr.2012.10.006 Text en © 2012 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Case Report
Kaufman, Kenneth R.
Velez, Arnaldo E.
Wong, Stephen
Mani, Ram
Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()
title Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()
title_full Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()
title_fullStr Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()
title_full_unstemmed Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()
title_short Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review()()
title_sort low-dose lacosamide-induced atrial fibrillation: case analysis with literature review()()
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150593/
https://www.ncbi.nlm.nih.gov/pubmed/25688049
http://dx.doi.org/10.1016/j.ebcr.2012.10.006
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AT wongstephen lowdoselacosamideinducedatrialfibrillationcaseanalysiswithliteraturereview
AT maniram lowdoselacosamideinducedatrialfibrillationcaseanalysiswithliteraturereview

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