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EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas()
Late seizure relapses following temporal lobectomy for drug-resistant temporal lobe epilepsy occur in 18–30% of operated-on cases, and recent evidence suggests that a significant proportion of them are due to maturation and activation of proepileptic tissue having defied initial resection and locate...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150631/ https://www.ncbi.nlm.nih.gov/pubmed/25667852 http://dx.doi.org/10.1016/j.ebcr.2013.09.001 |
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author | Garganis, Kyriakos Kokkinos, Vasileios Zountsas, Basilios |
author_facet | Garganis, Kyriakos Kokkinos, Vasileios Zountsas, Basilios |
author_sort | Garganis, Kyriakos |
collection | PubMed |
description | Late seizure relapses following temporal lobectomy for drug-resistant temporal lobe epilepsy occur in 18–30% of operated-on cases, and recent evidence suggests that a significant proportion of them are due to maturation and activation of proepileptic tissue having defied initial resection and located at the vicinity of or at a short distance from its borders, usually over the posterior medial, basal temporal-occipital, and lateral temporal regions. Experimental studies in animals and functional imaging studies in humans suggest that the area tempestas, a particular region of the basal-frontal piriform cortex, is critical for kindling and initiation and propagation of seizure activity arising from different cortical foci, especially limbic ones. This case report of a patient with late seizure relapse, three years following an initially successful right temporal lobectomy for ipsilateral medial temporal sclerosis, is the first one in the literature to demonstrate interictal EEG–fMRI evidence of significant BOLD signal changes over the inferior, basal and lateral temporal and temporooccipital cortices posterior to the resection margin, plus a significant BOLD signal change over the ipsilateral basal frontal region, closely corresponding to the piriform cortex/area tempestas. Our case study provides further functional imaging evidence in support of maturation/activation of proepileptic tissue located at the vicinity of the initial temporal lobe resection in cases of late seizure relapses and suggests, in addition, a possible role for the piriform cortex/area tempestas in the relapsing process. |
format | Online Article Text |
id | pubmed-4150631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-41506312015-02-09 EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() Garganis, Kyriakos Kokkinos, Vasileios Zountsas, Basilios Epilepsy Behav Case Rep Case Report Late seizure relapses following temporal lobectomy for drug-resistant temporal lobe epilepsy occur in 18–30% of operated-on cases, and recent evidence suggests that a significant proportion of them are due to maturation and activation of proepileptic tissue having defied initial resection and located at the vicinity of or at a short distance from its borders, usually over the posterior medial, basal temporal-occipital, and lateral temporal regions. Experimental studies in animals and functional imaging studies in humans suggest that the area tempestas, a particular region of the basal-frontal piriform cortex, is critical for kindling and initiation and propagation of seizure activity arising from different cortical foci, especially limbic ones. This case report of a patient with late seizure relapse, three years following an initially successful right temporal lobectomy for ipsilateral medial temporal sclerosis, is the first one in the literature to demonstrate interictal EEG–fMRI evidence of significant BOLD signal changes over the inferior, basal and lateral temporal and temporooccipital cortices posterior to the resection margin, plus a significant BOLD signal change over the ipsilateral basal frontal region, closely corresponding to the piriform cortex/area tempestas. Our case study provides further functional imaging evidence in support of maturation/activation of proepileptic tissue located at the vicinity of the initial temporal lobe resection in cases of late seizure relapses and suggests, in addition, a possible role for the piriform cortex/area tempestas in the relapsing process. Elsevier 2013-10-12 /pmc/articles/PMC4150631/ /pubmed/25667852 http://dx.doi.org/10.1016/j.ebcr.2013.09.001 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Case Report Garganis, Kyriakos Kokkinos, Vasileios Zountsas, Basilios EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() |
title | EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() |
title_full | EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() |
title_fullStr | EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() |
title_full_unstemmed | EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() |
title_short | EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas() |
title_sort | eeg–fmri findings in late seizure recurrence following temporal lobectomy: a possible contribution of area tempestas() |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150631/ https://www.ncbi.nlm.nih.gov/pubmed/25667852 http://dx.doi.org/10.1016/j.ebcr.2013.09.001 |
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