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Seizure control in a patient with Dravet syndrome and cystic fibrosis()
Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the cour...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150651/ https://www.ncbi.nlm.nih.gov/pubmed/25667824 http://dx.doi.org/10.1016/j.ebcr.2013.02.001 |
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author | Schmalbach, Barbara Moeller, Bettina von Spiczak, Sarah Muhle, Hiltrud Stephani, Ulrich Lang, Nicolas |
author_facet | Schmalbach, Barbara Moeller, Bettina von Spiczak, Sarah Muhle, Hiltrud Stephani, Ulrich Lang, Nicolas |
author_sort | Schmalbach, Barbara |
collection | PubMed |
description | Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the course of his disease: additionally to DS, the patient was diagnosed with cystic fibrosis (CF), another genetic channelopathy. Seizure freedom could be achieved under treatment with potassium bromide at the age of 15, but at the age of 20, adverse events made it necessary to stop bromide treatment. After conversion to valproic acid, the patient remained seizure-free, and neuropsychological tests demonstrated sustained improvement of cognition. |
format | Online Article Text |
id | pubmed-4150651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-41506512015-02-09 Seizure control in a patient with Dravet syndrome and cystic fibrosis() Schmalbach, Barbara Moeller, Bettina von Spiczak, Sarah Muhle, Hiltrud Stephani, Ulrich Lang, Nicolas Epilepsy Behav Case Rep Case Report Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the course of his disease: additionally to DS, the patient was diagnosed with cystic fibrosis (CF), another genetic channelopathy. Seizure freedom could be achieved under treatment with potassium bromide at the age of 15, but at the age of 20, adverse events made it necessary to stop bromide treatment. After conversion to valproic acid, the patient remained seizure-free, and neuropsychological tests demonstrated sustained improvement of cognition. Elsevier 2013-03-29 /pmc/articles/PMC4150651/ /pubmed/25667824 http://dx.doi.org/10.1016/j.ebcr.2013.02.001 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) . |
spellingShingle | Case Report Schmalbach, Barbara Moeller, Bettina von Spiczak, Sarah Muhle, Hiltrud Stephani, Ulrich Lang, Nicolas Seizure control in a patient with Dravet syndrome and cystic fibrosis() |
title | Seizure control in a patient with Dravet syndrome and cystic fibrosis() |
title_full | Seizure control in a patient with Dravet syndrome and cystic fibrosis() |
title_fullStr | Seizure control in a patient with Dravet syndrome and cystic fibrosis() |
title_full_unstemmed | Seizure control in a patient with Dravet syndrome and cystic fibrosis() |
title_short | Seizure control in a patient with Dravet syndrome and cystic fibrosis() |
title_sort | seizure control in a patient with dravet syndrome and cystic fibrosis() |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150651/ https://www.ncbi.nlm.nih.gov/pubmed/25667824 http://dx.doi.org/10.1016/j.ebcr.2013.02.001 |
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