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Seizure control in a patient with Dravet syndrome and cystic fibrosis()

Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the cour...

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Autores principales: Schmalbach, Barbara, Moeller, Bettina, von Spiczak, Sarah, Muhle, Hiltrud, Stephani, Ulrich, Lang, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150651/
https://www.ncbi.nlm.nih.gov/pubmed/25667824
http://dx.doi.org/10.1016/j.ebcr.2013.02.001
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author Schmalbach, Barbara
Moeller, Bettina
von Spiczak, Sarah
Muhle, Hiltrud
Stephani, Ulrich
Lang, Nicolas
author_facet Schmalbach, Barbara
Moeller, Bettina
von Spiczak, Sarah
Muhle, Hiltrud
Stephani, Ulrich
Lang, Nicolas
author_sort Schmalbach, Barbara
collection PubMed
description Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the course of his disease: additionally to DS, the patient was diagnosed with cystic fibrosis (CF), another genetic channelopathy. Seizure freedom could be achieved under treatment with potassium bromide at the age of 15, but at the age of 20, adverse events made it necessary to stop bromide treatment. After conversion to valproic acid, the patient remained seizure-free, and neuropsychological tests demonstrated sustained improvement of cognition.
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spelling pubmed-41506512015-02-09 Seizure control in a patient with Dravet syndrome and cystic fibrosis() Schmalbach, Barbara Moeller, Bettina von Spiczak, Sarah Muhle, Hiltrud Stephani, Ulrich Lang, Nicolas Epilepsy Behav Case Rep Case Report Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the course of his disease: additionally to DS, the patient was diagnosed with cystic fibrosis (CF), another genetic channelopathy. Seizure freedom could be achieved under treatment with potassium bromide at the age of 15, but at the age of 20, adverse events made it necessary to stop bromide treatment. After conversion to valproic acid, the patient remained seizure-free, and neuropsychological tests demonstrated sustained improvement of cognition. Elsevier 2013-03-29 /pmc/articles/PMC4150651/ /pubmed/25667824 http://dx.doi.org/10.1016/j.ebcr.2013.02.001 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Case Report
Schmalbach, Barbara
Moeller, Bettina
von Spiczak, Sarah
Muhle, Hiltrud
Stephani, Ulrich
Lang, Nicolas
Seizure control in a patient with Dravet syndrome and cystic fibrosis()
title Seizure control in a patient with Dravet syndrome and cystic fibrosis()
title_full Seizure control in a patient with Dravet syndrome and cystic fibrosis()
title_fullStr Seizure control in a patient with Dravet syndrome and cystic fibrosis()
title_full_unstemmed Seizure control in a patient with Dravet syndrome and cystic fibrosis()
title_short Seizure control in a patient with Dravet syndrome and cystic fibrosis()
title_sort seizure control in a patient with dravet syndrome and cystic fibrosis()
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150651/
https://www.ncbi.nlm.nih.gov/pubmed/25667824
http://dx.doi.org/10.1016/j.ebcr.2013.02.001
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