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Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()

We report a case of sustained ventricular tachycardia following the initiation of lacosamide as adjunctive epilepsy treatment. A 49-year-old male with intractable frontal lobe seizures experienced severe ventricular tachycardia following the addition of 400 mg lacosamide to his existing regimen of c...

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Autores principales: DeGiorgio, Andrew C., Desso, Tamara E., Lee, Lance, DeGiorgio, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150657/
https://www.ncbi.nlm.nih.gov/pubmed/25688050
http://dx.doi.org/10.1016/j.ebcr.2012.10.001
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author DeGiorgio, Andrew C.
Desso, Tamara E.
Lee, Lance
DeGiorgio, Christopher M.
author_facet DeGiorgio, Andrew C.
Desso, Tamara E.
Lee, Lance
DeGiorgio, Christopher M.
author_sort DeGiorgio, Andrew C.
collection PubMed
description We report a case of sustained ventricular tachycardia following the initiation of lacosamide as adjunctive epilepsy treatment. A 49-year-old male with intractable frontal lobe seizures experienced severe ventricular tachycardia following the addition of 400 mg lacosamide to his existing regimen of carbamazepine, lamotrigine, clonazepam, and valproate. The tachycardia occurred during a cardiac stress test; stress tests prior to initiation of lacosamide were normal. Conduction defects, including QRS prolongation, persisted during hospitalization until lacosamide was discontinued. The patient had no prior history of cardiac arrhythmia but did possess cardiac risk factors, including hypertension, hypercholesterolemia, and low heart rate variability. This case represents one part of a growing body of literature suggesting a link between arrhythmia and use of lacosamide, which enhances slow inactivation of sodium channels in both the brain and the heart. We believe further study may be necessary to assess the safety of lacosamide in epilepsy patients with cardiac risk factors.
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spelling pubmed-41506572015-02-09 Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy() DeGiorgio, Andrew C. Desso, Tamara E. Lee, Lance DeGiorgio, Christopher M. Epilepsy Behav Case Rep Case Report We report a case of sustained ventricular tachycardia following the initiation of lacosamide as adjunctive epilepsy treatment. A 49-year-old male with intractable frontal lobe seizures experienced severe ventricular tachycardia following the addition of 400 mg lacosamide to his existing regimen of carbamazepine, lamotrigine, clonazepam, and valproate. The tachycardia occurred during a cardiac stress test; stress tests prior to initiation of lacosamide were normal. Conduction defects, including QRS prolongation, persisted during hospitalization until lacosamide was discontinued. The patient had no prior history of cardiac arrhythmia but did possess cardiac risk factors, including hypertension, hypercholesterolemia, and low heart rate variability. This case represents one part of a growing body of literature suggesting a link between arrhythmia and use of lacosamide, which enhances slow inactivation of sodium channels in both the brain and the heart. We believe further study may be necessary to assess the safety of lacosamide in epilepsy patients with cardiac risk factors. Elsevier 2012-11-07 /pmc/articles/PMC4150657/ /pubmed/25688050 http://dx.doi.org/10.1016/j.ebcr.2012.10.001 Text en © 2012 The Authors. Published by Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Case Report
DeGiorgio, Andrew C.
Desso, Tamara E.
Lee, Lance
DeGiorgio, Christopher M.
Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
title Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
title_full Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
title_fullStr Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
title_full_unstemmed Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
title_short Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
title_sort ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy()
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150657/
https://www.ncbi.nlm.nih.gov/pubmed/25688050
http://dx.doi.org/10.1016/j.ebcr.2012.10.001
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