Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog

NONO, SFPQ and PSPC1 make up a family of proteins with diverse roles in transcription, RNA processing and DNA double-strand break (DSB) repair. To understand long-term effects of loss of NONO, we characterized murine embryonic fibroblasts (MEFs) from knockout mice. In the absence of genotoxic stress...

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Detalles Bibliográficos
Autores principales: Li, Shuyi, Li, Zhentian, Shu, Feng-Jue, Xiong, Hairong, Phillips, Andrew C., Dynan, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150768/
https://www.ncbi.nlm.nih.gov/pubmed/25100870
http://dx.doi.org/10.1093/nar/gku650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150768/
https://www.ncbi.nlm.nih.gov/pubmed/25100870
http://dx.doi.org/10.1093/nar/gku650

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