Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase

Considering that all natural nucleotides (D-dNTPs) and the building blocks (D-dNMPs) of DNA chains possess D-stereochemistry, DNA polymerases and reverse transcriptases (RTs) likely possess strongD-stereoselectivity by preferably binding and incorporating D-dNTPs over unnatural L-dNTPs during DNA sy...

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Detalles Bibliográficos
Autores principales: Gaur, Vineet, Vyas, Rajan, Fowler, Jason D., Efthimiopoulos, Georgia, Feng, Joy Y., Suo, Zucai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150803/
https://www.ncbi.nlm.nih.gov/pubmed/25104018
http://dx.doi.org/10.1093/nar/gku709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150803/
https://www.ncbi.nlm.nih.gov/pubmed/25104018
http://dx.doi.org/10.1093/nar/gku709

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