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Targeted gene suppression by inducing de novo DNA methylation in the gene promoter

BACKGROUND: Targeted gene silencing is an important approach in both drug development and basic research. However, the selection of a potent suppressor has become a significant hurdle to implementing maximal gene inhibition for this approach. We attempted to construct a ‘super suppressor’ by combini...

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Detalles Bibliográficos
Autores principales:	Ma, Ai-Niu, Wang, Hong, Guo, Rui, Wang, Yong-Xiang, Li, Wei, Cui, Jiuwei, Wang, Guanjun, Hoffman, Andrew R, Hu, Ji-Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150861/ https://www.ncbi.nlm.nih.gov/pubmed/25184003 http://dx.doi.org/10.1186/1756-8935-7-20

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