Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer

Chronic inflammation is an established risk factor for the onset of cancer, and the inflammatory cytokine IL-6 has a role in tumorigenesis by enhancing proliferation and hindering apoptosis. As factors stimulating proliferation also downregulate p53 expression by enhancing ribosome biogenesis, we hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Brighenti, E, Calabrese, C, Liguori, G, Giannone, F A, Trerè, D, Montanaro, L, Derenzini, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150990/
https://www.ncbi.nlm.nih.gov/pubmed/24531714
http://dx.doi.org/10.1038/onc.2014.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150990/
https://www.ncbi.nlm.nih.gov/pubmed/24531714
http://dx.doi.org/10.1038/onc.2014.1

Ejemplares similares