Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study

There have been a number of studies about correlations between HLA genotypes in various ethnic groups and occurrence of various cutaneous adverse drug reactions, ranging in intensity from mild to severe, caused by antiepileptic drugs (AEDs). This is the first report analyzing the HLA genotypes of 9...

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Autores principales: Song, Ju Sun, Kang, Eun-Suk, Joo, Eun Yeon, Hong, Seung Bong, Seo, Dae-Won, Lee, Soo-Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151006/
https://www.ncbi.nlm.nih.gov/pubmed/25187890
http://dx.doi.org/10.3343/alm.2014.34.5.372
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author Song, Ju Sun
Kang, Eun-Suk
Joo, Eun Yeon
Hong, Seung Bong
Seo, Dae-Won
Lee, Soo-Youn
author_facet Song, Ju Sun
Kang, Eun-Suk
Joo, Eun Yeon
Hong, Seung Bong
Seo, Dae-Won
Lee, Soo-Youn
author_sort Song, Ju Sun
collection PubMed
description There have been a number of studies about correlations between HLA genotypes in various ethnic groups and occurrence of various cutaneous adverse drug reactions, ranging in intensity from mild to severe, caused by antiepileptic drugs (AEDs). This is the first report analyzing the HLA genotypes of 9 Korean patients with skin rashes induced by various AEDs. The AEDs that induced skin rash were lamotrigine (n=3), carbamazepine (n=3), oxcarbazepine (n=1), phenobarbital (n=1), and phenytoin (n=1). None of the patients' HLA genotypes was either HLA-B(*)1502 or HLA-A(*)3101. Based on these series of cases, AED-induced skin rash can occur independently of HLA-B(*)1502 or HLA-A(*)3101 genotypes in the Korean patients.
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spelling pubmed-41510062014-09-03 Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study Song, Ju Sun Kang, Eun-Suk Joo, Eun Yeon Hong, Seung Bong Seo, Dae-Won Lee, Soo-Youn Ann Lab Med Brief Communication There have been a number of studies about correlations between HLA genotypes in various ethnic groups and occurrence of various cutaneous adverse drug reactions, ranging in intensity from mild to severe, caused by antiepileptic drugs (AEDs). This is the first report analyzing the HLA genotypes of 9 Korean patients with skin rashes induced by various AEDs. The AEDs that induced skin rash were lamotrigine (n=3), carbamazepine (n=3), oxcarbazepine (n=1), phenobarbital (n=1), and phenytoin (n=1). None of the patients' HLA genotypes was either HLA-B(*)1502 or HLA-A(*)3101. Based on these series of cases, AED-induced skin rash can occur independently of HLA-B(*)1502 or HLA-A(*)3101 genotypes in the Korean patients. The Korean Society for Laboratory Medicine 2014-09 2014-08-21 /pmc/articles/PMC4151006/ /pubmed/25187890 http://dx.doi.org/10.3343/alm.2014.34.5.372 Text en © The Korean Society for Laboratory Medicine. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Song, Ju Sun
Kang, Eun-Suk
Joo, Eun Yeon
Hong, Seung Bong
Seo, Dae-Won
Lee, Soo-Youn
Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study
title Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study
title_full Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study
title_fullStr Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study
title_full_unstemmed Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study
title_short Absence of HLA-B(*)1502 and HLA-A(*)3101 Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study
title_sort absence of hla-b(*)1502 and hla-a(*)3101 alleles in 9 korean patients with antiepileptic drug-induced skin rash: a preliminary study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151006/
https://www.ncbi.nlm.nih.gov/pubmed/25187890
http://dx.doi.org/10.3343/alm.2014.34.5.372
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