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Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks

The gene regulatory network (GRN) is the central decision‐making module of the cell. We have developed a theory called Buffered Qualitative Stability (BQS) based on the hypothesis that GRNs are organised so that they remain robust in the face of unpredictable environmental and evolutionary changes....

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Detalles Bibliográficos
Autores principales: Albergante, Luca, Blow, J Julian, Newman, Timothy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151086/
https://www.ncbi.nlm.nih.gov/pubmed/25182846
http://dx.doi.org/10.7554/eLife.02863
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author Albergante, Luca
Blow, J Julian
Newman, Timothy J
author_facet Albergante, Luca
Blow, J Julian
Newman, Timothy J
author_sort Albergante, Luca
collection PubMed
description The gene regulatory network (GRN) is the central decision‐making module of the cell. We have developed a theory called Buffered Qualitative Stability (BQS) based on the hypothesis that GRNs are organised so that they remain robust in the face of unpredictable environmental and evolutionary changes. BQS makes strong and diverse predictions about the network features that allow stable responses under arbitrary perturbations, including the random addition of new connections. We show that the GRNs of E. coli, M. tuberculosis, P. aeruginosa, yeast, mouse, and human all verify the predictions of BQS. BQS explains many of the small- and large‐scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response. BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation. DOI: http://dx.doi.org/10.7554/eLife.02863.001
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spelling pubmed-41510862014-10-17 Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks Albergante, Luca Blow, J Julian Newman, Timothy J eLife Genomics and Evolutionary Biology The gene regulatory network (GRN) is the central decision‐making module of the cell. We have developed a theory called Buffered Qualitative Stability (BQS) based on the hypothesis that GRNs are organised so that they remain robust in the face of unpredictable environmental and evolutionary changes. BQS makes strong and diverse predictions about the network features that allow stable responses under arbitrary perturbations, including the random addition of new connections. We show that the GRNs of E. coli, M. tuberculosis, P. aeruginosa, yeast, mouse, and human all verify the predictions of BQS. BQS explains many of the small- and large‐scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response. BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation. DOI: http://dx.doi.org/10.7554/eLife.02863.001 eLife Sciences Publications, Ltd 2014-09-02 /pmc/articles/PMC4151086/ /pubmed/25182846 http://dx.doi.org/10.7554/eLife.02863 Text en Copyright © 2014, Albergante et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Genomics and Evolutionary Biology
Albergante, Luca
Blow, J Julian
Newman, Timothy J
Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
title Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
title_full Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
title_fullStr Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
title_full_unstemmed Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
title_short Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
title_sort buffered qualitative stability explains the robustness and evolvability of transcriptional networks
topic Genomics and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151086/
https://www.ncbi.nlm.nih.gov/pubmed/25182846
http://dx.doi.org/10.7554/eLife.02863
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