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Concise Chemoenzymatic Three-Step Total Synthesis of Isosolenopsin through Medium Engineering
A short and efficient total synthesis of the alkaloid isosolenopsin and its enantiomer has been achieved. The key step was a ω-transaminase-catalysed regioselective monoamination of the diketone pentadecane-2,6-dione, which was obtained in a single step through the application of a Grignard reaction...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151137/ https://www.ncbi.nlm.nih.gov/pubmed/25191103 http://dx.doi.org/10.1002/ejoc.201300157 |