Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation

BACKGROUND: Human prion diseases are caused by abnormal accumulation of misfolded prion protein in the brain tissue. Inherited prion diseases, including familial Creutzfeldt-Jakob disease (fCJD), are associated with mutations of the prion protein gene (PRNP). The glutamate (E)-to-lysine (K) substitu...

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Detalles Bibliográficos
Autores principales: Lee, Sol Moe, Chung, Myungguen, Hwang, Kyu Jam, Ju, Young Ran, Hyeon, Jae Wook, Park, Jun-Sun, Kim, Chi-Kyeong, Choi, Sangho, Lee, Jeongmin, Kim, Su Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151374/
https://www.ncbi.nlm.nih.gov/pubmed/25149502
http://dx.doi.org/10.1186/1755-8794-7-52

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