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Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls w...

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Autores principales: Gurbuzer, Nurbanu, Gozke, Eren, Ayhan Basturk, Zeliha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151543/
https://www.ncbi.nlm.nih.gov/pubmed/25202453
http://dx.doi.org/10.1155/2014/170626
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author Gurbuzer, Nurbanu
Gozke, Eren
Ayhan Basturk, Zeliha
author_facet Gurbuzer, Nurbanu
Gozke, Eren
Ayhan Basturk, Zeliha
author_sort Gurbuzer, Nurbanu
collection PubMed
description Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P < 0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P < 0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.
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spelling pubmed-41515432014-09-08 Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke Gurbuzer, Nurbanu Gozke, Eren Ayhan Basturk, Zeliha Cardiovasc Psychiatry Neurol Research Article Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P < 0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P < 0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels. Hindawi Publishing Corporation 2014 2014-08-18 /pmc/articles/PMC4151543/ /pubmed/25202453 http://dx.doi.org/10.1155/2014/170626 Text en Copyright © 2014 Nurbanu Gurbuzer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gurbuzer, Nurbanu
Gozke, Eren
Ayhan Basturk, Zeliha
Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke
title Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke
title_full Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke
title_fullStr Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke
title_full_unstemmed Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke
title_short Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke
title_sort gamma-glutamyl transferase levels in patients with acute ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151543/
https://www.ncbi.nlm.nih.gov/pubmed/25202453
http://dx.doi.org/10.1155/2014/170626
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