Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO(4)) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO(4) in rats. ZnY or ZnSO(4) were orally administered to rats at a single dos...

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Detalles Bibliográficos
Autores principales: Zhang, Shuangqing, Zhang, Yan, Peng, Ning, Zhang, Haibo, Yao, Juan, Li, Zhihong, Liu, Liegang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151581/
https://www.ncbi.nlm.nih.gov/pubmed/25215316
http://dx.doi.org/10.1155/2014/217142
Descripción
Sumario:Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO(4)) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO(4) in rats. ZnY or ZnSO(4) were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO(4), respectively. Both ZnY and ZnSO(4) were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO(4), the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO(4).

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