Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO(4)) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO(4) in rats. ZnY or ZnSO(4) were orally administered to rats at a single dos...

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Autores principales: Zhang, Shuangqing, Zhang, Yan, Peng, Ning, Zhang, Haibo, Yao, Juan, Li, Zhihong, Liu, Liegang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151581/
https://www.ncbi.nlm.nih.gov/pubmed/25215316
http://dx.doi.org/10.1155/2014/217142
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author Zhang, Shuangqing
Zhang, Yan
Peng, Ning
Zhang, Haibo
Yao, Juan
Li, Zhihong
Liu, Liegang
author_facet Zhang, Shuangqing
Zhang, Yan
Peng, Ning
Zhang, Haibo
Yao, Juan
Li, Zhihong
Liu, Liegang
author_sort Zhang, Shuangqing
collection PubMed
description Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO(4)) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO(4) in rats. ZnY or ZnSO(4) were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO(4), respectively. Both ZnY and ZnSO(4) were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO(4), the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO(4).
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spelling pubmed-41515812014-09-11 Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats Zhang, Shuangqing Zhang, Yan Peng, Ning Zhang, Haibo Yao, Juan Li, Zhihong Liu, Liegang ScientificWorldJournal Research Article Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO(4)) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO(4) in rats. ZnY or ZnSO(4) were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO(4), respectively. Both ZnY and ZnSO(4) were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO(4), the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO(4). Hindawi Publishing Corporation 2014 2014-08-17 /pmc/articles/PMC4151581/ /pubmed/25215316 http://dx.doi.org/10.1155/2014/217142 Text en Copyright © 2014 Shuangqing Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Shuangqing
Zhang, Yan
Peng, Ning
Zhang, Haibo
Yao, Juan
Li, Zhihong
Liu, Liegang
Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_full Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_fullStr Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_full_unstemmed Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_short Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
title_sort pharmacokinetics and biodistribution of zinc-enriched yeast in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151581/
https://www.ncbi.nlm.nih.gov/pubmed/25215316
http://dx.doi.org/10.1155/2014/217142
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