Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking

Corneal cross-linking (CXL) is increasingly performed in ophthalmology with high success rates for progressive keratoconus and other types of ectasia. Despite being an established procedure, some molecular and clinical aspects still require additional studies. This review presents a critical analysi...

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Detalles Bibliográficos
Autores principales: da Paz, Amanda C., Bersanetti, Patrícia A., Salomão, Marcella Q., Ambrósio, Renato, Schor, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151584/
https://www.ncbi.nlm.nih.gov/pubmed/25215226
http://dx.doi.org/10.1155/2014/890823
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author da Paz, Amanda C.
Bersanetti, Patrícia A.
Salomão, Marcella Q.
Ambrósio, Renato
Schor, Paulo
author_facet da Paz, Amanda C.
Bersanetti, Patrícia A.
Salomão, Marcella Q.
Ambrósio, Renato
Schor, Paulo
author_sort da Paz, Amanda C.
collection PubMed
description Corneal cross-linking (CXL) is increasingly performed in ophthalmology with high success rates for progressive keratoconus and other types of ectasia. Despite being an established procedure, some molecular and clinical aspects still require additional studies. This review presents a critical analysis of some established topics and others that are still controversial. In addition, this review examines new technologies and techniques (transepithelial and ultrafast CXL), uses of corneal CXL including natural products and biomolecules as CXL promoters, and evidence for in vitro and in vivo indirect effectiveness.
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spelling pubmed-41515842014-09-11 Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking da Paz, Amanda C. Bersanetti, Patrícia A. Salomão, Marcella Q. Ambrósio, Renato Schor, Paulo J Ophthalmol Review Article Corneal cross-linking (CXL) is increasingly performed in ophthalmology with high success rates for progressive keratoconus and other types of ectasia. Despite being an established procedure, some molecular and clinical aspects still require additional studies. This review presents a critical analysis of some established topics and others that are still controversial. In addition, this review examines new technologies and techniques (transepithelial and ultrafast CXL), uses of corneal CXL including natural products and biomolecules as CXL promoters, and evidence for in vitro and in vivo indirect effectiveness. Hindawi Publishing Corporation 2014 2014-08-18 /pmc/articles/PMC4151584/ /pubmed/25215226 http://dx.doi.org/10.1155/2014/890823 Text en Copyright © 2014 Amanda C. da Paz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
da Paz, Amanda C.
Bersanetti, Patrícia A.
Salomão, Marcella Q.
Ambrósio, Renato
Schor, Paulo
Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking
title Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking
title_full Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking
title_fullStr Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking
title_full_unstemmed Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking
title_short Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking
title_sort theoretical basis, laboratory evidence, and clinical research of chemical surgery of the cornea: cross-linking
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151584/
https://www.ncbi.nlm.nih.gov/pubmed/25215226
http://dx.doi.org/10.1155/2014/890823
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