Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

[Image: see text] Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positive) topoisomerase IV through a cr...

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Detalles Bibliográficos
Autores principales: Aldred, Katie J., Breland, Erin J., Vlčková, Vladislava, Strub, Marie-Paule, Neuman, Keir C., Kerns, Robert J., Osheroff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151693/
https://www.ncbi.nlm.nih.gov/pubmed/25115926
http://dx.doi.org/10.1021/bi500682e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151693/
https://www.ncbi.nlm.nih.gov/pubmed/25115926
http://dx.doi.org/10.1021/bi500682e

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