Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions

[Image: see text] Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we report the design and development of new o-quinone-based catalysts for the oxidative dehydrogenation of tetrahydroquinolines to afford quinolines. Use of a...

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Autores principales: Wendlandt, Alison E., Stahl, Shannon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151779/
https://www.ncbi.nlm.nih.gov/pubmed/25109345
http://dx.doi.org/10.1021/ja506546w
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author Wendlandt, Alison E.
Stahl, Shannon S.
author_facet Wendlandt, Alison E.
Stahl, Shannon S.
author_sort Wendlandt, Alison E.
collection PubMed
description [Image: see text] Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we report the design and development of new o-quinone-based catalysts for the oxidative dehydrogenation of tetrahydroquinolines to afford quinolines. Use of a Co(salophen) cocatalyst allows the reaction to proceed efficiently with ambient air at room temperature. The utility of the catalytic method is demonstrated in the preparation of a number of medicinally relevant quinolines.
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spelling pubmed-41517792015-08-11 Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions Wendlandt, Alison E. Stahl, Shannon S. J Am Chem Soc [Image: see text] Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we report the design and development of new o-quinone-based catalysts for the oxidative dehydrogenation of tetrahydroquinolines to afford quinolines. Use of a Co(salophen) cocatalyst allows the reaction to proceed efficiently with ambient air at room temperature. The utility of the catalytic method is demonstrated in the preparation of a number of medicinally relevant quinolines. American Chemical Society 2014-08-11 2014-08-27 /pmc/articles/PMC4151779/ /pubmed/25109345 http://dx.doi.org/10.1021/ja506546w Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Wendlandt, Alison E.
Stahl, Shannon S.
Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
title Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
title_full Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
title_fullStr Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
title_full_unstemmed Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
title_short Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
title_sort modular o-quinone catalyst system for dehydrogenation of tetrahydroquinolines under ambient conditions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151779/
https://www.ncbi.nlm.nih.gov/pubmed/25109345
http://dx.doi.org/10.1021/ja506546w
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