Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes

In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentat...

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Autores principales: Puddu, Alessandra, Sanguineti, Roberta, Montecucco, Fabrizio, Viviani, Giorgio Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151858/
https://www.ncbi.nlm.nih.gov/pubmed/25214711
http://dx.doi.org/10.1155/2014/162021
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author Puddu, Alessandra
Sanguineti, Roberta
Montecucco, Fabrizio
Viviani, Giorgio Luciano
author_facet Puddu, Alessandra
Sanguineti, Roberta
Montecucco, Fabrizio
Viviani, Giorgio Luciano
author_sort Puddu, Alessandra
collection PubMed
description In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.
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spelling pubmed-41518582014-09-11 Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes Puddu, Alessandra Sanguineti, Roberta Montecucco, Fabrizio Viviani, Giorgio Luciano Mediators Inflamm Review Article In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes. Hindawi Publishing Corporation 2014 2014-08-17 /pmc/articles/PMC4151858/ /pubmed/25214711 http://dx.doi.org/10.1155/2014/162021 Text en Copyright © 2014 Alessandra Puddu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Puddu, Alessandra
Sanguineti, Roberta
Montecucco, Fabrizio
Viviani, Giorgio Luciano
Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
title Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
title_full Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
title_fullStr Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
title_full_unstemmed Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
title_short Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
title_sort evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151858/
https://www.ncbi.nlm.nih.gov/pubmed/25214711
http://dx.doi.org/10.1155/2014/162021
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