Inhibition of the MDM2 E3 Ligase Induces Apoptosis and Autophagy in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically with ABT-737

Intracellular proteolytic pathways have been validated as rational targets in multiple myeloma with the approval of two proteasome inhibitors in this disease, and with the finding that immunomodulatory agents work through an E3 ubiquitin ligase containing Cereblon. Another E3 ligase that could be a...

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Detalles Bibliográficos
Autores principales: Gu, Dongmin, Wang, Shuhong, Kuiatse, Isere, Wang, Hua, He, Jin, Dai, Yun, Jones, Richard J., Bjorklund, Chad C., Yang, Jing, Grant, Steven, Orlowski, Robert Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151993/
https://www.ncbi.nlm.nih.gov/pubmed/25181509
http://dx.doi.org/10.1371/journal.pone.0103015

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