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Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010
Recent global malaria burden modeling efforts have produced significantly different estimates, particularly in adult malaria mortality. To measure malaria control progress, accurate malaria burden estimates across age groups are necessary. We determined age-specific malaria mortality rates in wester...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152016/ https://www.ncbi.nlm.nih.gov/pubmed/25180495 http://dx.doi.org/10.1371/journal.pone.0106197 |
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author | Desai, Meghna Buff, Ann M. Khagayi, Sammy Byass, Peter Amek, Nyaguara van Eijk, Annemieke Slutsker, Laurence Vulule, John Odhiambo, Frank O. Phillips-Howard, Penelope A. Lindblade, Kimberly A. Laserson, Kayla F. Hamel, Mary J. |
author_facet | Desai, Meghna Buff, Ann M. Khagayi, Sammy Byass, Peter Amek, Nyaguara van Eijk, Annemieke Slutsker, Laurence Vulule, John Odhiambo, Frank O. Phillips-Howard, Penelope A. Lindblade, Kimberly A. Laserson, Kayla F. Hamel, Mary J. |
author_sort | Desai, Meghna |
collection | PubMed |
description | Recent global malaria burden modeling efforts have produced significantly different estimates, particularly in adult malaria mortality. To measure malaria control progress, accurate malaria burden estimates across age groups are necessary. We determined age-specific malaria mortality rates in western Kenya to compare with recent global estimates. We collected data from 148,000 persons in a health and demographic surveillance system from 2003–2010. Standardized verbal autopsies were conducted for all deaths; probable cause of death was assigned using the InterVA-4 model. Annual malaria mortality rates per 1,000 person-years were generated by age group. Trends were analyzed using Poisson regression. From 2003–2010, in children <5 years the malaria mortality rate decreased from 13.2 to 3.7 per 1,000 person-years; the declines were greatest in the first three years of life. In children 5–14 years, the malaria mortality rate remained stable at 0.5 per 1,000 person-years. In persons ≥15 years, the malaria mortality rate decreased from 1.5 to 0.4 per 1,000 person-years. The malaria mortality rates in young children and persons aged ≥15 years decreased dramatically from 2003–2010 in western Kenya, but rates in older children have not declined. Sharp declines in some age groups likely reflect the national scale up of malaria control interventions and rapid expansion of HIV prevention services. These data highlight the importance of age-specific malaria mortality ascertainment and support current strategies to include all age groups in malaria control interventions. |
format | Online Article Text |
id | pubmed-4152016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41520162014-09-05 Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 Desai, Meghna Buff, Ann M. Khagayi, Sammy Byass, Peter Amek, Nyaguara van Eijk, Annemieke Slutsker, Laurence Vulule, John Odhiambo, Frank O. Phillips-Howard, Penelope A. Lindblade, Kimberly A. Laserson, Kayla F. Hamel, Mary J. PLoS One Research Article Recent global malaria burden modeling efforts have produced significantly different estimates, particularly in adult malaria mortality. To measure malaria control progress, accurate malaria burden estimates across age groups are necessary. We determined age-specific malaria mortality rates in western Kenya to compare with recent global estimates. We collected data from 148,000 persons in a health and demographic surveillance system from 2003–2010. Standardized verbal autopsies were conducted for all deaths; probable cause of death was assigned using the InterVA-4 model. Annual malaria mortality rates per 1,000 person-years were generated by age group. Trends were analyzed using Poisson regression. From 2003–2010, in children <5 years the malaria mortality rate decreased from 13.2 to 3.7 per 1,000 person-years; the declines were greatest in the first three years of life. In children 5–14 years, the malaria mortality rate remained stable at 0.5 per 1,000 person-years. In persons ≥15 years, the malaria mortality rate decreased from 1.5 to 0.4 per 1,000 person-years. The malaria mortality rates in young children and persons aged ≥15 years decreased dramatically from 2003–2010 in western Kenya, but rates in older children have not declined. Sharp declines in some age groups likely reflect the national scale up of malaria control interventions and rapid expansion of HIV prevention services. These data highlight the importance of age-specific malaria mortality ascertainment and support current strategies to include all age groups in malaria control interventions. Public Library of Science 2014-09-02 /pmc/articles/PMC4152016/ /pubmed/25180495 http://dx.doi.org/10.1371/journal.pone.0106197 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Desai, Meghna Buff, Ann M. Khagayi, Sammy Byass, Peter Amek, Nyaguara van Eijk, Annemieke Slutsker, Laurence Vulule, John Odhiambo, Frank O. Phillips-Howard, Penelope A. Lindblade, Kimberly A. Laserson, Kayla F. Hamel, Mary J. Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 |
title | Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 |
title_full | Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 |
title_fullStr | Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 |
title_full_unstemmed | Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 |
title_short | Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010 |
title_sort | age-specific malaria mortality rates in the kemri/cdc health and demographic surveillance system in western kenya, 2003–2010 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152016/ https://www.ncbi.nlm.nih.gov/pubmed/25180495 http://dx.doi.org/10.1371/journal.pone.0106197 |
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