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mTOR Inhibition Induces Compensatory, Therapeutically Targetable MEK Activation in Renal Cell Carcinoma
Rapamycin derivatives allosterically targeting mTOR are currently FDA approved to treat advanced renal cell carcinoma (RCC), and catalytic inhibitors of mTOR/PI3K are now in clinical trials for treating various solid tumors. We sought to investigate the relative efficacy of allosteric versus catalyt...
Autores principales: | Bailey, Sean T., Zhou, Bing, Damrauer, Jeffrey S., Krishnan, Bhavani, Wilson, Harper L., Smith, Aleisha M., Li, Mingqing, Yeh, Jen Jen, Kim, William Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152178/ https://www.ncbi.nlm.nih.gov/pubmed/25180793 http://dx.doi.org/10.1371/journal.pone.0104413 |
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