A Regulatory Polymorphism in HAVCR2 Modulates Susceptibility to HIV-1 Infection

The HAVCR2 gene encodes TIM-3, an immunoglobulin superfamily member expressed by exhausted CD8+ T cells during chronic viral infection. We investigated whether genetic variation at HAVCR2 modulates the susceptibility to HIV-1 acquisition; specifically we focused on a 3′ UTR variant (rs4704846, A/G)...

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Detalles Bibliográficos
Autores principales: Sironi, Manuela, Biasin, Mara, Gnudi, Federica, Cagliani, Rachele, Saulle, Irma, Forni, Diego, Rainone, Veronica, Trabattoni, Daria, Garziano, Micaela, Mazzotta, Francesco, Real, Luis Miguel, Rivero-Juarez, Antonio, Caruz, Antonio, Caputo, Sergio Lo, Clerici, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152274/
https://www.ncbi.nlm.nih.gov/pubmed/25180498
http://dx.doi.org/10.1371/journal.pone.0106442

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