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Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma
Malignant melanoma is the most aggressive form of skin cancer and has been traditionally considered difficult to treat. The worldwide incidence of melanoma has been increasing faster than any other type of cancer. Early detection, surgery, and adjuvant therapy enable improved outcomes; nonetheless,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152551/ https://www.ncbi.nlm.nih.gov/pubmed/25317253 http://dx.doi.org/10.3402/nano.v5.24381 |
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author | Monge-Fuentes, Victoria Muehlmann, Luis Alexandre de Azevedo, Ricardo Bentes |
author_facet | Monge-Fuentes, Victoria Muehlmann, Luis Alexandre de Azevedo, Ricardo Bentes |
author_sort | Monge-Fuentes, Victoria |
collection | PubMed |
description | Malignant melanoma is the most aggressive form of skin cancer and has been traditionally considered difficult to treat. The worldwide incidence of melanoma has been increasing faster than any other type of cancer. Early detection, surgery, and adjuvant therapy enable improved outcomes; nonetheless, the prognosis of metastatic melanoma remains poor. Several therapies have been investigated for the treatment of melanoma; however, current treatment options for patients with metastatic disease are limited and non-curative in the majority of cases. Photodynamic therapy (PDT) has been proposed as a promising minimally invasive therapeutic procedure that employs three essential elements to induce cell death: a photosensitizer, light of a specific wavelength, and molecular oxygen. However, classical PDT has shown some drawbacks that limit its clinical application. In view of this, the use of nanotechnology has been considered since it provides many tools that can be applied to PDT to circumvent these limitations and bring new perspectives for the application of this therapy for different types of diseases. On that ground, this review focuses on the potential use of developing nanotechnologies able to bring significant benefits for anticancer PDT, aiming to reach higher efficacy and safety for patients with malignant melanoma. |
format | Online Article Text |
id | pubmed-4152551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-41525512014-10-14 Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma Monge-Fuentes, Victoria Muehlmann, Luis Alexandre de Azevedo, Ricardo Bentes Nano Rev Invited Review Article Malignant melanoma is the most aggressive form of skin cancer and has been traditionally considered difficult to treat. The worldwide incidence of melanoma has been increasing faster than any other type of cancer. Early detection, surgery, and adjuvant therapy enable improved outcomes; nonetheless, the prognosis of metastatic melanoma remains poor. Several therapies have been investigated for the treatment of melanoma; however, current treatment options for patients with metastatic disease are limited and non-curative in the majority of cases. Photodynamic therapy (PDT) has been proposed as a promising minimally invasive therapeutic procedure that employs three essential elements to induce cell death: a photosensitizer, light of a specific wavelength, and molecular oxygen. However, classical PDT has shown some drawbacks that limit its clinical application. In view of this, the use of nanotechnology has been considered since it provides many tools that can be applied to PDT to circumvent these limitations and bring new perspectives for the application of this therapy for different types of diseases. On that ground, this review focuses on the potential use of developing nanotechnologies able to bring significant benefits for anticancer PDT, aiming to reach higher efficacy and safety for patients with malignant melanoma. Co-Action Publishing 2014-09-01 /pmc/articles/PMC4152551/ /pubmed/25317253 http://dx.doi.org/10.3402/nano.v5.24381 Text en © 2014 Victoria Monge-Fuentes et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Article Monge-Fuentes, Victoria Muehlmann, Luis Alexandre de Azevedo, Ricardo Bentes Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
title | Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
title_full | Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
title_fullStr | Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
title_full_unstemmed | Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
title_short | Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
title_sort | perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma |
topic | Invited Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152551/ https://www.ncbi.nlm.nih.gov/pubmed/25317253 http://dx.doi.org/10.3402/nano.v5.24381 |
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