Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming

Maintaining the self-renewal of embryonic stem cells (ESCs) could be achieved by activating the extrinsic signaling, i.e., the use of leukemia inhibitory factor (LIF), or blocking the intrinsic differentiation pathways, i.e., the use of GSK3 and MEK inhibitors (2i). Here we found that even in medium...

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Detalles Bibliográficos
Autores principales: Chen, Guofang, Xu, Xinxiu, Zhang, Lihong, Fu, Yanbin, Wang, Min, Gu, Haifeng, Xie, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152737/
https://www.ncbi.nlm.nih.gov/pubmed/25145356
http://dx.doi.org/10.1038/cr.2014.112

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