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Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer

Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel cent...

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Autores principales: Murray, Nigel P., Reyes, Eduardo, Fuentealba, Cynthia, Orellana, Nelson, Jacob, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152931/
https://www.ncbi.nlm.nih.gov/pubmed/25210517
http://dx.doi.org/10.1155/2014/612674
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author Murray, Nigel P.
Reyes, Eduardo
Fuentealba, Cynthia
Orellana, Nelson
Jacob, Omar
author_facet Murray, Nigel P.
Reyes, Eduardo
Fuentealba, Cynthia
Orellana, Nelson
Jacob, Omar
author_sort Murray, Nigel P.
collection PubMed
description Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel centrifugation and detected using standard immunocytochemistry using anti-PSA; positive samples underwent a second process with anti-P504S. A malignant primary CPC was defined as PSA (+) P504S (+) and a test positive if 1 cell/4 mL was detected. Biopsy results were registered as cancer/no-cancer, number of cores positive, and percent infiltration of the cores. Results. 328/1123 (29.2%) of the study population had prostate cancer diagnosed on initial biopsy, and 42/328 (12.8%) were negative for primary CPCs. CPC negative men were significantly older, and had lower PSA levels, lower Gleason scores, and fewer positive cores and with infiltration by the cancer. 38/42 (91%) of CPC negative men complied with the criteria for active surveillance in comparison with 34/286 (12%) of CPC positive men. Conclusions. Using primary CPC detection as a sequential test to select men with an elevated PSA for biopsy, the risk of missing clinically significant prostate cancer is minimal when the patient is primary CPC negative; less than 0.5% of all primary CPC negative men had a clinically significant prostate cancer.
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spelling pubmed-41529312014-09-10 Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer Murray, Nigel P. Reyes, Eduardo Fuentealba, Cynthia Orellana, Nelson Jacob, Omar J Oncol Research Article Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel centrifugation and detected using standard immunocytochemistry using anti-PSA; positive samples underwent a second process with anti-P504S. A malignant primary CPC was defined as PSA (+) P504S (+) and a test positive if 1 cell/4 mL was detected. Biopsy results were registered as cancer/no-cancer, number of cores positive, and percent infiltration of the cores. Results. 328/1123 (29.2%) of the study population had prostate cancer diagnosed on initial biopsy, and 42/328 (12.8%) were negative for primary CPCs. CPC negative men were significantly older, and had lower PSA levels, lower Gleason scores, and fewer positive cores and with infiltration by the cancer. 38/42 (91%) of CPC negative men complied with the criteria for active surveillance in comparison with 34/286 (12%) of CPC positive men. Conclusions. Using primary CPC detection as a sequential test to select men with an elevated PSA for biopsy, the risk of missing clinically significant prostate cancer is minimal when the patient is primary CPC negative; less than 0.5% of all primary CPC negative men had a clinically significant prostate cancer. Hindawi Publishing Corporation 2014 2014-08-19 /pmc/articles/PMC4152931/ /pubmed/25210517 http://dx.doi.org/10.1155/2014/612674 Text en Copyright © 2014 Nigel P. Murray et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Murray, Nigel P.
Reyes, Eduardo
Fuentealba, Cynthia
Orellana, Nelson
Jacob, Omar
Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
title Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
title_full Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
title_fullStr Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
title_full_unstemmed Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
title_short Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
title_sort primary circulating prostate cells are not detected in men with low grade small volume prostate cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152931/
https://www.ncbi.nlm.nih.gov/pubmed/25210517
http://dx.doi.org/10.1155/2014/612674
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