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Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel cent...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152931/ https://www.ncbi.nlm.nih.gov/pubmed/25210517 http://dx.doi.org/10.1155/2014/612674 |
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author | Murray, Nigel P. Reyes, Eduardo Fuentealba, Cynthia Orellana, Nelson Jacob, Omar |
author_facet | Murray, Nigel P. Reyes, Eduardo Fuentealba, Cynthia Orellana, Nelson Jacob, Omar |
author_sort | Murray, Nigel P. |
collection | PubMed |
description | Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel centrifugation and detected using standard immunocytochemistry using anti-PSA; positive samples underwent a second process with anti-P504S. A malignant primary CPC was defined as PSA (+) P504S (+) and a test positive if 1 cell/4 mL was detected. Biopsy results were registered as cancer/no-cancer, number of cores positive, and percent infiltration of the cores. Results. 328/1123 (29.2%) of the study population had prostate cancer diagnosed on initial biopsy, and 42/328 (12.8%) were negative for primary CPCs. CPC negative men were significantly older, and had lower PSA levels, lower Gleason scores, and fewer positive cores and with infiltration by the cancer. 38/42 (91%) of CPC negative men complied with the criteria for active surveillance in comparison with 34/286 (12%) of CPC positive men. Conclusions. Using primary CPC detection as a sequential test to select men with an elevated PSA for biopsy, the risk of missing clinically significant prostate cancer is minimal when the patient is primary CPC negative; less than 0.5% of all primary CPC negative men had a clinically significant prostate cancer. |
format | Online Article Text |
id | pubmed-4152931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41529312014-09-10 Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer Murray, Nigel P. Reyes, Eduardo Fuentealba, Cynthia Orellana, Nelson Jacob, Omar J Oncol Research Article Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel centrifugation and detected using standard immunocytochemistry using anti-PSA; positive samples underwent a second process with anti-P504S. A malignant primary CPC was defined as PSA (+) P504S (+) and a test positive if 1 cell/4 mL was detected. Biopsy results were registered as cancer/no-cancer, number of cores positive, and percent infiltration of the cores. Results. 328/1123 (29.2%) of the study population had prostate cancer diagnosed on initial biopsy, and 42/328 (12.8%) were negative for primary CPCs. CPC negative men were significantly older, and had lower PSA levels, lower Gleason scores, and fewer positive cores and with infiltration by the cancer. 38/42 (91%) of CPC negative men complied with the criteria for active surveillance in comparison with 34/286 (12%) of CPC positive men. Conclusions. Using primary CPC detection as a sequential test to select men with an elevated PSA for biopsy, the risk of missing clinically significant prostate cancer is minimal when the patient is primary CPC negative; less than 0.5% of all primary CPC negative men had a clinically significant prostate cancer. Hindawi Publishing Corporation 2014 2014-08-19 /pmc/articles/PMC4152931/ /pubmed/25210517 http://dx.doi.org/10.1155/2014/612674 Text en Copyright © 2014 Nigel P. Murray et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Murray, Nigel P. Reyes, Eduardo Fuentealba, Cynthia Orellana, Nelson Jacob, Omar Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer |
title | Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer |
title_full | Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer |
title_fullStr | Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer |
title_full_unstemmed | Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer |
title_short | Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer |
title_sort | primary circulating prostate cells are not detected in men with low grade small volume prostate cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152931/ https://www.ncbi.nlm.nih.gov/pubmed/25210517 http://dx.doi.org/10.1155/2014/612674 |
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