Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is fine-tuned and controlled by adenosine acting...

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Detalles Bibliográficos
Autores principales: Vieira, Cátia, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Silva, Isabel, Dias, Ana Sofia, Pelletier, Julie, Sévigny, Jean, Correia-de-Sá, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152956/
https://www.ncbi.nlm.nih.gov/pubmed/25210228
http://dx.doi.org/10.1155/2014/254640

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