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Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators

BACKGROUND: The results of bronchodilator therapy in chronic obstructive pulmonary disease (COPD) are not satisfactory and because of this, many drugs are administered for treatment of disease. We examined the short-term additive bronchodilator effects of tiotropium in patients with stable COPD alre...

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Autor principal: Nicolini, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153178/
https://www.ncbi.nlm.nih.gov/pubmed/25191397
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author Nicolini, Antonello
author_facet Nicolini, Antonello
author_sort Nicolini, Antonello
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description BACKGROUND: The results of bronchodilator therapy in chronic obstructive pulmonary disease (COPD) are not satisfactory and because of this, many drugs are administered for treatment of disease. We examined the short-term additive bronchodilator effects of tiotropium in patients with stable COPD already treated with salmeterol twice daily. MATERIALS AND METHODS: In a double-blind, double-dummy randomized study we evaluated the acute bronchodilator efficacy of a single 18 µg dose of tiotropium in patients with COPD under chronic treatment with a long acting beta-adrenergic (salmeterol 50µg twice a day). Measurements of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and six-minute walking test (6 MWT) as indicator of daily activities were made before and after giving the drug. A total of 129 outpatients with stable COPD (Gold level 2 -3- 4) were enrolled and 92 completed the study. RESULTS: Tiotropium elicited a significantly greater bronchodilation than the placebo. The action of the drug was elicited as increase in FEV1 (p ≤ 0.001) and FVC (p ≤ 0.001); 6-MWT increased 35 meters in patients treated with tiotropium compared to 2.5 meters in those receiving placebo (p ≤ 0.001). CONCLUSION: Addition of tiotropium to chronic administration of a beta-adrenergic drug such as salmeterol induced an increase in pulmonary function parameters and in exercise capacity suggesting that association of the two drugs can be more efficient for treatment of disease and improvement of daily living activities than beta-adrenergics alone.
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spelling pubmed-41531782014-09-04 Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators Nicolini, Antonello Tanaffos Original Article BACKGROUND: The results of bronchodilator therapy in chronic obstructive pulmonary disease (COPD) are not satisfactory and because of this, many drugs are administered for treatment of disease. We examined the short-term additive bronchodilator effects of tiotropium in patients with stable COPD already treated with salmeterol twice daily. MATERIALS AND METHODS: In a double-blind, double-dummy randomized study we evaluated the acute bronchodilator efficacy of a single 18 µg dose of tiotropium in patients with COPD under chronic treatment with a long acting beta-adrenergic (salmeterol 50µg twice a day). Measurements of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and six-minute walking test (6 MWT) as indicator of daily activities were made before and after giving the drug. A total of 129 outpatients with stable COPD (Gold level 2 -3- 4) were enrolled and 92 completed the study. RESULTS: Tiotropium elicited a significantly greater bronchodilation than the placebo. The action of the drug was elicited as increase in FEV1 (p ≤ 0.001) and FVC (p ≤ 0.001); 6-MWT increased 35 meters in patients treated with tiotropium compared to 2.5 meters in those receiving placebo (p ≤ 0.001). CONCLUSION: Addition of tiotropium to chronic administration of a beta-adrenergic drug such as salmeterol induced an increase in pulmonary function parameters and in exercise capacity suggesting that association of the two drugs can be more efficient for treatment of disease and improvement of daily living activities than beta-adrenergics alone. National Research Institute of Tuberculosis and Lung Disease 2012 /pmc/articles/PMC4153178/ /pubmed/25191397 Text en Copyright © 2012 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Nicolini, Antonello
Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators
title Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators
title_full Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators
title_fullStr Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators
title_full_unstemmed Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators
title_short Short Term Effects of Tiotropium on COPD Patients Treated with Long Acting Bronchodilators
title_sort short term effects of tiotropium on copd patients treated with long acting bronchodilators
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153178/
https://www.ncbi.nlm.nih.gov/pubmed/25191397
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