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Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome

Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is excep...

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Autores principales: Guha, Pradipta, Sarkar, Debasis, Ray, Arindam, Thakur, Indranil, Mukherjee, Sekhar, Chatterjee, Sanjoy Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153222/
https://www.ncbi.nlm.nih.gov/pubmed/25191441
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author Guha, Pradipta
Sarkar, Debasis
Ray, Arindam
Thakur, Indranil
Mukherjee, Sekhar
Chatterjee, Sanjoy Kumar
author_facet Guha, Pradipta
Sarkar, Debasis
Ray, Arindam
Thakur, Indranil
Mukherjee, Sekhar
Chatterjee, Sanjoy Kumar
author_sort Guha, Pradipta
collection PubMed
description Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is exceptional in elderly men and the outcome is rarely fatal. We report a case of LCCSCT in a 44 year-old man with fatal outcome. The tumor involved the right testis and several areas of the tunica albuginea were grossly invaded. It composed of cords and trabeculae of large polygonal cells embedded in a myxoid and fibrous stroma with areas of calcification along with nuclear atypia, necrosis, and abundant mitoses. The Peutz-Jeghers syndrome (PJS) is known to be commonly associated with ovarian tumors. However, its association with testicular tumors is uncommon. To the best of our knowledge, this is the eight such case being reported in the literature. Our case, to our knowledge, is the only other reported case of malignant large cell calcifying Sertoli cell tumor with clinical and histopathological features related to aggressiveness, such as large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. Such characteristics are not found in benign large cell calcifying Sertoli cell tumors.
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spelling pubmed-41532222014-09-04 Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome Guha, Pradipta Sarkar, Debasis Ray, Arindam Thakur, Indranil Mukherjee, Sekhar Chatterjee, Sanjoy Kumar Tanaffos Case Report Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is exceptional in elderly men and the outcome is rarely fatal. We report a case of LCCSCT in a 44 year-old man with fatal outcome. The tumor involved the right testis and several areas of the tunica albuginea were grossly invaded. It composed of cords and trabeculae of large polygonal cells embedded in a myxoid and fibrous stroma with areas of calcification along with nuclear atypia, necrosis, and abundant mitoses. The Peutz-Jeghers syndrome (PJS) is known to be commonly associated with ovarian tumors. However, its association with testicular tumors is uncommon. To the best of our knowledge, this is the eight such case being reported in the literature. Our case, to our knowledge, is the only other reported case of malignant large cell calcifying Sertoli cell tumor with clinical and histopathological features related to aggressiveness, such as large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. Such characteristics are not found in benign large cell calcifying Sertoli cell tumors. National Research Institute of Tuberculosis and Lung Disease 2012 /pmc/articles/PMC4153222/ /pubmed/25191441 Text en Copyright © 2012 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Case Report
Guha, Pradipta
Sarkar, Debasis
Ray, Arindam
Thakur, Indranil
Mukherjee, Sekhar
Chatterjee, Sanjoy Kumar
Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
title Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
title_full Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
title_fullStr Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
title_full_unstemmed Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
title_short Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
title_sort malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153222/
https://www.ncbi.nlm.nih.gov/pubmed/25191441
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