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Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome
Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is excep...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Research Institute of Tuberculosis and Lung Disease
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153222/ https://www.ncbi.nlm.nih.gov/pubmed/25191441 |
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author | Guha, Pradipta Sarkar, Debasis Ray, Arindam Thakur, Indranil Mukherjee, Sekhar Chatterjee, Sanjoy Kumar |
author_facet | Guha, Pradipta Sarkar, Debasis Ray, Arindam Thakur, Indranil Mukherjee, Sekhar Chatterjee, Sanjoy Kumar |
author_sort | Guha, Pradipta |
collection | PubMed |
description | Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is exceptional in elderly men and the outcome is rarely fatal. We report a case of LCCSCT in a 44 year-old man with fatal outcome. The tumor involved the right testis and several areas of the tunica albuginea were grossly invaded. It composed of cords and trabeculae of large polygonal cells embedded in a myxoid and fibrous stroma with areas of calcification along with nuclear atypia, necrosis, and abundant mitoses. The Peutz-Jeghers syndrome (PJS) is known to be commonly associated with ovarian tumors. However, its association with testicular tumors is uncommon. To the best of our knowledge, this is the eight such case being reported in the literature. Our case, to our knowledge, is the only other reported case of malignant large cell calcifying Sertoli cell tumor with clinical and histopathological features related to aggressiveness, such as large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. Such characteristics are not found in benign large cell calcifying Sertoli cell tumors. |
format | Online Article Text |
id | pubmed-4153222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | National Research Institute of Tuberculosis and Lung Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-41532222014-09-04 Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome Guha, Pradipta Sarkar, Debasis Ray, Arindam Thakur, Indranil Mukherjee, Sekhar Chatterjee, Sanjoy Kumar Tanaffos Case Report Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is exceptional in elderly men and the outcome is rarely fatal. We report a case of LCCSCT in a 44 year-old man with fatal outcome. The tumor involved the right testis and several areas of the tunica albuginea were grossly invaded. It composed of cords and trabeculae of large polygonal cells embedded in a myxoid and fibrous stroma with areas of calcification along with nuclear atypia, necrosis, and abundant mitoses. The Peutz-Jeghers syndrome (PJS) is known to be commonly associated with ovarian tumors. However, its association with testicular tumors is uncommon. To the best of our knowledge, this is the eight such case being reported in the literature. Our case, to our knowledge, is the only other reported case of malignant large cell calcifying Sertoli cell tumor with clinical and histopathological features related to aggressiveness, such as large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. Such characteristics are not found in benign large cell calcifying Sertoli cell tumors. National Research Institute of Tuberculosis and Lung Disease 2012 /pmc/articles/PMC4153222/ /pubmed/25191441 Text en Copyright © 2012 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Case Report Guha, Pradipta Sarkar, Debasis Ray, Arindam Thakur, Indranil Mukherjee, Sekhar Chatterjee, Sanjoy Kumar Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome |
title | Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome |
title_full | Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome |
title_fullStr | Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome |
title_full_unstemmed | Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome |
title_short | Malignant Large Cell Calcifying Sertoli Cell Tumor of Testis with Skip Metastasis to Lung Presented With Peutz-Jeghers Syndrome |
title_sort | malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153222/ https://www.ncbi.nlm.nih.gov/pubmed/25191441 |
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