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Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug–drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153445/ https://www.ncbi.nlm.nih.gov/pubmed/24682030 http://dx.doi.org/10.1038/clpt.2014.70 |
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author | Wulkersdorfer, B Wanek, T Bauer, M Zeitlinger, M Müller, M Langer, O |
author_facet | Wulkersdorfer, B Wanek, T Bauer, M Zeitlinger, M Müller, M Langer, O |
author_sort | Wulkersdorfer, B |
collection | PubMed |
description | Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug–drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)—a noninvasive imaging method—plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs. |
format | Online Article Text |
id | pubmed-4153445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-41534452014-09-08 Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues Wulkersdorfer, B Wanek, T Bauer, M Zeitlinger, M Müller, M Langer, O Clin Pharmacol Ther Reviews Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug–drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)—a noninvasive imaging method—plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs. Nature Publishing Group 2014-08 2014-04-30 /pmc/articles/PMC4153445/ /pubmed/24682030 http://dx.doi.org/10.1038/clpt.2014.70 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Reviews Wulkersdorfer, B Wanek, T Bauer, M Zeitlinger, M Müller, M Langer, O Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues |
title | Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues |
title_full | Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues |
title_fullStr | Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues |
title_full_unstemmed | Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues |
title_short | Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues |
title_sort | using positron emission tomography to study transporter-mediated drug–drug interactions in tissues |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153445/ https://www.ncbi.nlm.nih.gov/pubmed/24682030 http://dx.doi.org/10.1038/clpt.2014.70 |
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