Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues

Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug–drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, p...

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Autores principales: Wulkersdorfer, B, Wanek, T, Bauer, M, Zeitlinger, M, Müller, M, Langer, O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153445/
https://www.ncbi.nlm.nih.gov/pubmed/24682030
http://dx.doi.org/10.1038/clpt.2014.70
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author Wulkersdorfer, B
Wanek, T
Bauer, M
Zeitlinger, M
Müller, M
Langer, O
author_facet Wulkersdorfer, B
Wanek, T
Bauer, M
Zeitlinger, M
Müller, M
Langer, O
author_sort Wulkersdorfer, B
collection PubMed
description Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug–drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)—a noninvasive imaging method—plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs.
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spelling pubmed-41534452014-09-08 Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues Wulkersdorfer, B Wanek, T Bauer, M Zeitlinger, M Müller, M Langer, O Clin Pharmacol Ther Reviews Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug–drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)—a noninvasive imaging method—plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs. Nature Publishing Group 2014-08 2014-04-30 /pmc/articles/PMC4153445/ /pubmed/24682030 http://dx.doi.org/10.1038/clpt.2014.70 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Reviews
Wulkersdorfer, B
Wanek, T
Bauer, M
Zeitlinger, M
Müller, M
Langer, O
Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
title Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
title_full Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
title_fullStr Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
title_full_unstemmed Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
title_short Using Positron Emission Tomography to Study Transporter-Mediated Drug–Drug Interactions in Tissues
title_sort using positron emission tomography to study transporter-mediated drug–drug interactions in tissues
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153445/
https://www.ncbi.nlm.nih.gov/pubmed/24682030
http://dx.doi.org/10.1038/clpt.2014.70
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