Specific elimination of mutant mitochondrial genomes in patient–derived cells by mitoTALENs

Mitochondrial diseases are commonly caused by mutations in the mitochondrial DNA (mtDNA), which in most cases co–exists with the wild–type (mtDNA heteroplasmy). We have engineered TAL–effector nucleases (TALENs) to localize to mitochondria and cleave different classes of pathogenic mtDNA mutations....

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Detalles Bibliográficos
Autores principales: Bacman, Sandra R., Williams, Siôn L., Pinto, Milena, Peralta, Susana, Moraes, Carlos T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153471/
https://www.ncbi.nlm.nih.gov/pubmed/23913125
http://dx.doi.org/10.1038/nm.3261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153471/
https://www.ncbi.nlm.nih.gov/pubmed/23913125
http://dx.doi.org/10.1038/nm.3261

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