Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction

Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cogniti...

Descripción completa

Detalles Bibliográficos
Autores principales: Bi, Yanlin, Liu, Shuyun, Yu, Xinjuan, Wang, Mingshan, Wang, Yuelan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Technical Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153513/
https://www.ncbi.nlm.nih.gov/pubmed/25206851
http://dx.doi.org/10.4103/1673-5374.130084
_version_ 1782333290953310208
author Bi, Yanlin
Liu, Shuyun
Yu, Xinjuan
Wang, Mingshan
Wang, Yuelan
author_facet Bi, Yanlin
Liu, Shuyun
Yu, Xinjuan
Wang, Mingshan
Wang, Yuelan
author_sort Bi, Yanlin
collection PubMed
description Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′ adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1–7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.
format Online
Article
Text
id pubmed-4153513
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-41535132014-09-09 Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction Bi, Yanlin Liu, Shuyun Yu, Xinjuan Wang, Mingshan Wang, Yuelan Neural Regen Res Technical Updates Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′ adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1–7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats. Medknow Publications & Media Pvt Ltd 2014-03-01 /pmc/articles/PMC4153513/ /pubmed/25206851 http://dx.doi.org/10.4103/1673-5374.130084 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Updates
Bi, Yanlin
Liu, Shuyun
Yu, Xinjuan
Wang, Mingshan
Wang, Yuelan
Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
title Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
title_full Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
title_fullStr Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
title_full_unstemmed Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
title_short Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
title_sort adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
topic Technical Updates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153513/
https://www.ncbi.nlm.nih.gov/pubmed/25206851
http://dx.doi.org/10.4103/1673-5374.130084
work_keys_str_mv AT biyanlin adaptiveandregulatorymechanismsinagedratswithpostoperativecognitivedysfunction
AT liushuyun adaptiveandregulatorymechanismsinagedratswithpostoperativecognitivedysfunction
AT yuxinjuan adaptiveandregulatorymechanismsinagedratswithpostoperativecognitivedysfunction
AT wangmingshan adaptiveandregulatorymechanismsinagedratswithpostoperativecognitivedysfunction
AT wangyuelan adaptiveandregulatorymechanismsinagedratswithpostoperativecognitivedysfunction

Ejemplares similares