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Rural and urban microbiota: To be or not to be?

A multitude of metagenomic studies has brought to light an enormous richness of human gut microbiota compositions. In this space of possible configurations, clinical specialists are trying to mine the markers of healthy microbiota via case-control and longitudinal studies. We have discovered potenti...

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Detalles Bibliográficos
Autores principales: Tyakht, Alexander V, Alexeev, Dmitry G, Popenko, Anna S, Kostryukova, Elena S, Govorun, Vadim M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153773/
https://www.ncbi.nlm.nih.gov/pubmed/24691073
http://dx.doi.org/10.4161/gmic.28685
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author Tyakht, Alexander V
Alexeev, Dmitry G
Popenko, Anna S
Kostryukova, Elena S
Govorun, Vadim M
author_facet Tyakht, Alexander V
Alexeev, Dmitry G
Popenko, Anna S
Kostryukova, Elena S
Govorun, Vadim M
author_sort Tyakht, Alexander V
collection PubMed
description A multitude of metagenomic studies has brought to light an enormous richness of human gut microbiota compositions. In this space of possible configurations, clinical specialists are trying to mine the markers of healthy microbiota via case-control and longitudinal studies. We have discovered potentially beneficial communities while examining the microbial diversity in rural Russians in comparison with the urban dwellers. In this addendum, we further examine the data by elaborating on some of the less common types and suggesting the possible co-metabolism of their drivers. In the light of the first validated clinically effective bacterial transplantation, we discuss the concept of a reference healthy microbiota, outline the problems encountered on the way to its restoration in the developed world, and speculate if rural communities can serve as a source for its prototype.
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spelling pubmed-41537732015-05-01 Rural and urban microbiota: To be or not to be? Tyakht, Alexander V Alexeev, Dmitry G Popenko, Anna S Kostryukova, Elena S Govorun, Vadim M Gut Microbes Article Addendum A multitude of metagenomic studies has brought to light an enormous richness of human gut microbiota compositions. In this space of possible configurations, clinical specialists are trying to mine the markers of healthy microbiota via case-control and longitudinal studies. We have discovered potentially beneficial communities while examining the microbial diversity in rural Russians in comparison with the urban dwellers. In this addendum, we further examine the data by elaborating on some of the less common types and suggesting the possible co-metabolism of their drivers. In the light of the first validated clinically effective bacterial transplantation, we discuss the concept of a reference healthy microbiota, outline the problems encountered on the way to its restoration in the developed world, and speculate if rural communities can serve as a source for its prototype. Landes Bioscience 2014-05-01 2014-04-01 /pmc/articles/PMC4153773/ /pubmed/24691073 http://dx.doi.org/10.4161/gmic.28685 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Tyakht, Alexander V
Alexeev, Dmitry G
Popenko, Anna S
Kostryukova, Elena S
Govorun, Vadim M
Rural and urban microbiota: To be or not to be?
title Rural and urban microbiota: To be or not to be?
title_full Rural and urban microbiota: To be or not to be?
title_fullStr Rural and urban microbiota: To be or not to be?
title_full_unstemmed Rural and urban microbiota: To be or not to be?
title_short Rural and urban microbiota: To be or not to be?
title_sort rural and urban microbiota: to be or not to be?
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153773/
https://www.ncbi.nlm.nih.gov/pubmed/24691073
http://dx.doi.org/10.4161/gmic.28685
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